Assessment of Reasons and Pattern of Treatment Interruption during Intensive Phase of MDR-TB Treatment
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 4
Abstract
Treatment interruptions are not uncommon during treatment of multidrug resistant tuberculosis (MDR-TB). Identification and management of factors contributing to treatment interruptions may leads to better treatment adherence and outcomes. Study was conducted with aim to assess overall causes of treatment interruption and to identify its pattern during intensive phase (IP) of standardized MDR TB regimen under programme conditions at Drug Resistant Tuberculosis Centre (DR-TB) Ajmer (Rajasthan) India. All eligible patients were followed at end of IP for exploring treatment interruption and its associated reasons. Data related to MDR-TB treatment were reviewed and extracted retrospectively from treatment cards and master cards maintained at DR-TB centre. Total 126 patients were followed at the end of intensive phase. There were 100 (79.3%) males and 26 (20.6%) females in study group. The mean age of cohort was 38.1 years. A total 31(24.6%) patients interrupted the treatment during intensive phase for variable periods. Most commonly, 13 patients (41.9%) interrupted the treatment for duration between 8-30 days, followed by 12 patients (38.7%) that missed the doses for duration of ≤ 7days. On assessment of overall cause of treatment interruption, the most common reason emerged was moving out of area (29%), followed by adverse drug reactions (19.3%). In conclusion, close supervision and training of DOT provider and management of adverse drug reactions are desirable for better treatment adherence and ultimately outcome.
Authors and Affiliations
Dr. Kamendra Singh Pawar
Keywords
Related Articles
- EP ID EP505297
- DOI -
- Views 99
- Downloads 0
An analysis of Choledochal Cysts in Adults.
Background Choledochal Cyst (CCD) is not an isolated entity but a constellation of pathological abnormalities in the pancreatohepatobiliary system. Alonso-Lej et al (1959) proposed an anatomical classification. Todani...
Family involvement in the care of hospitalized newborns: Experience Neonatal Center of Rabat
Background: Neonatal departments are designed to treat premature infants, low birth weight or presenting pathology during the neonatal period. Parents of babies hospitalized at birth are faced with a difficult situation...
A Study of Lipid Profile in Sickle Hemoglobinopathy Patients and Its Correlation with Pulmonary Hypertension and Hemolysis
Introduction: This study was planned to assess the lipid profile of patients of sickle hemoglobinopathy coming to our hospital and its possible relationship to vasculopathic complications such as PAH and hemolysis. Meth...
Ultrasonographic estimation of Gestational age on basis of Tibial length
Background- Appropriate assessment of gestational age is paramount in obstetric care. Making appropriate management decisions requires accurate appraisal of gestational age. Methods- The present study was conducted in th...
Spermatogenic Assessment in Mangiferin Induced Male Rats in Comparis0n to Crude Extract of Mangifera Indica (BARK)
Since ancient ages, mango tree is worshiped by the people of different counties like India .It has great economic as well as medical values in different fields of clinical treatment like fever, cough, hepatitis, diarrhoe...