Assessment of Serum Lipid Profile among Sudanese Patients with Malaria
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 5
Abstract
Changes in lipid profile are seen in many patients infected with malaria parasite. The malaria parasite causes hepatocellular damage and disturbs lipid handling by the liver. Inside hepatocytes and erythrocytes the parasite replicates rapidly scavenging cholesterol and lipids required for its growth and metabolism from the host. It also requires host lipids for detoxification of free heme to form the malarial pigment, haemozoin.Aim toAssess Serum lipid profile in patients with malaria in Khartoum state.Material and methods the present study was analytical cross-sectional study carried out during Sep 2016 to Dec 2016, at Khartoum State at alssagai rural hospital. Total of one hundred individuals were enrolled in this study, and classified into two groups 50 patients with malaria as case group and 50 healthy individuals as control group.Result as compared there is difference in HDL, LDL, cholesterol and triglycerides between malaria patients and control subjects (p<0.05). Patients with malaria showed low HDL (20.00 ±3.76mg/dL versus44.52 ± 4.85 mg/dL), low LdL (59.00 ±16.15 mg/dL versus107.76 ±9.76mg/dL), low cholesterol (114.78 ± 16.75mg/dL versus175.34 ± 16.83 mg/dL) and elevated triglycerides (172.4 ± 25.63mg/dL versus135.7 ± 11.66 mg/dL). The observations show a statistically significant. Conclusions malaria infection, both P. vivax and P. falciparum infections, causes derangements in lipid profile that are characterized by low serum, low HDL, low LDL and high triglyceride levels but differ in total cholesterol level . These derangements may be of diagnostic, prognostic or therapeutic value. Keywords:lipid profile, malaria.
Authors and Affiliations
Ibrahim YousifAbdalla Hamid, Amina Osman. M. Elzein, Abdelgaidr Eltom
Keywords
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