Assessment of Serum Low Density Lipoprotein Concentration by Friedewald Formula and By Direct Measurment by Spectrophotometric Kits.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 6
Abstract
Background and objective: The serum Low density Lipoprotein Cholesterol Concentration can be estimated by Freidewald formula and also by the direct assay methods by a spectrophotometer. The National Cholesterol Education program recommends the direct assay for estimating serum LDL-C concentration, but it has not been evaluated whether there is any difference between Freidwald formula & LDL-C direct assay methods in assessing Patients for CVD ( cardio vascular Disease). Methods: This study included the samples of 28,346 patients whose serum triglyceride level was less than 400 mg%. The study was carried in the month of January to May 2018. Fasting samples and non fasting samples were collected for measurement of lipid profile and commercial kits adapted to autoanalyser were used for the direct assay and Friedewald formula was used to calculate the value. Results: Serum LDL-C levels estimated by the direct method and Friedewald formula had a significant positive correlation (r = 0.968, p<0.001). The non fasting LDL-C level was higher than fasting sample. The LDL-C of fasting samples were in the same risk category in both the methods of estimation. Conclusion: The correlation of serum LDL-C level by both methods was significant. The risk assessment for CVD by the serum LDL-C level by both methods was similar, but the higher LDL-C level of non fasting samples may over calculate the risk.
Authors and Affiliations
Dr, Roma Rattan, Dr. Upendra Kumar Das, Dr Srikrushna Mahapatra
Keywords
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- EP ID EP375902
- DOI 10.9790/0853-1706044446.
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