Assessment of Sex Hormones (FSH, LH, Prolactin, Estrogen, Progesterone and Testosterone) of Pulmonary Tuberculosis Patients
Journal Title: Journal of Clinical Medical Research - Year 2024, Vol 5, Issue 3
Abstract
Background: Tuberculosis (TB) is a one of the major global health problems ranking as the eighth leading cause of death in low- and middle-income countries. This study was carried out to evaluate the Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin, Estrogen, Progesterone and Testosterone of pulmonary tuberculosis patients in Edo State. Objectives: The objectives of the study are to assess the FSH, LH, Prolactin, Estrogen, Progesterone and Testosterone levels of Pulmonary Tuberculosis (PTB) patients compared with control, hormonal levels of PTB patients of new case, 2 months and 6 months therapy compared with control, hormonal levels of PTB patients in relation to gender and hormonal levels of PTB patients in relation to age. Material and methods: A total of 120 samples were used in this study comprising PTB new cases (30), PTB 2 months therapy (30), PTB 6 months therapy (30) and Control (30) respectively. FSH, LH, Prolactin, Estrogen, Progesterone and Testosterone were measured by Enzyme-Linked Immunoassay Test (ELISA). The results were presented using tables as mean ± standard deviation. Statistical analysis was done using one-way Analysis of Variance (ANOVA) and the student’s t-test. Significant difference was accepted at p<0.05. Results: The results obtained showed that the FSH (mIU/ml) of new case subjects, 2 months on therapy, 6 months on therapy and control were 13.42±3.58, 11.38±3.04, 6.52±2.57 and 8.71±3.15; LH (mIU/ml) was 10.43±2.95, 8.32±2.44, 5.21±2.23 and 6.05±2.44; prolactin (µg/L) was 10.17±4.04, 9.47±2.56, 10.11±6.74 and 12.96±7.09; estrogen (pg/ml) was 35.97±9.27, 41.50±12.65, 57.60±17.46 and 64.97±29.24, progesterone (ng/ml) was 0.18±0.05, 0.25±0.06, 0.40±0.10 and 0.37±0.08; and testosterone (ng/ml) was 2.49±0.95, 2.48±1.46, 4.00±2.92 and 4.32±3.84 respectively. Conclusion: In conclusion, there was significant difference (p<0.05) in the FSH, LH, Prolactin, Estrogen, Progesterone and Testosterone of the subjects in the different groups compared with control. FSH, LH, Prolactin, Estrogen and Progesterone were significantly higher (p<0.05) in female subjects compared with male subjects, while Testosterone was non-significantly (p>0.05) higher in male subjects compared with female subjects.
Authors and Affiliations
Airhomwanbor KO1, Iyevhobu KO2,3*, Omolumen LE1, Asibor E4, Obohwemu KO5, Usiobeigbe OS1 , Akindele IA6 , Bisiriyu AH7, Oikerhe EG8, Ajayi FO9, Lagundoye SB10, Uwaifo NE11, Osaiyuwu OF12, Osaiyuwu OC13, Jabbo AA14, Edo EO14
Keywords
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- EP ID EP751280
- DOI https://doi.org/10.46889/JCMR.2024.5312
- Views 34
- Downloads 0
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