Assessment of the Amplitude-Frequency Characteristics of the Retina with Its Stimulation by Flicker and Chess Pattern-Reversed Incentives and their Use to Obtain New Formalized Signs of Retinal Pathologies
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 19, Issue 4
Abstract
Currently, an active search for new approaches to building expert systems for diagnosing retinal pathologies based on artificial intelligence methods (fuzzy logic methods, neural network approaches, modern classification methods, simulation models) is underway. The effectiveness of such expert systems depends entirely on the completeness of the available space of diagnostic features. The classical calculation of the amplitude and time parameters of the components of an electroretinogram (ERG) and their relations (indices), as well as the analysis of the frequency spectrum of the signal, becomes insufficient for interpreting the data obtained in the developed expert systems. In this paper, we propose and justify a method for estimating the amplitude-frequency characteristics (AFC) of the retina by processing the signals of the flicker ERG (FERG) and ERG responses to the chess pattern - black-and-white reversal cells (PERG). It is shown that the frequency response is an objective characteristic of the transfer properties of the retina, which depend not only on the type of stimuli acting on it but also on the etiology of retinal pathology. The purpose of the research is to search for additional formalized (digital) signs of retinal pathologies by analyzing the frequency response to expand the attribute space for diagnosis. The photopic FERG and transient PERG responses were recorded in six healthy individuals and six patients with stage I and stage II primary open-angle glaucoma (POAG). The digitized FERG and PERG signals were decomposed into a Fourier series and, taking into account the spectra of test stimuli, the retinal frequency response of different individuals was constructed, and their properties were studied as a dynamic object transforming the spectrum of the test stimulus into the spectrum of the recorded ERG. We proposed to use the coefficients of polynomials smoothing the resulting frequency response as new formalized diagnostic features. Each frequency response is submitted to be divided into two frequency ranges, and each of them uses its own algebraic smoothing polynomial. We used the results of modeling in Matlab Simulink to identify the characteristics of retinal responses to the flicker- and pattern-stimulation.
Authors and Affiliations
Zueva MV, Tsapenko IV, Kolosov OS, Vershinin DV, Korolenkovax VA, Pronin AD
Keywords
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- EP ID EP622674
- DOI 10.26717/BJSTR.2019.19.003358
- Views 141
- Downloads 0
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