Assessment of the changes in some diagnostics enzymes in fish Gambusia affinis treated with pesticide chlorpyrifos

Abstract

The acute toxicity of an organophosphorus pesticide chlorpyrifos on enzyme activities of fish Gambusia affinis was evaluated under statistic conditions. The fish is constantly exposed to pesticides, which are used extensively to control agricultural pests. Evaluation of toxic effect of chlorpyrifos on fish was carried out. Effect of sub lethal (LC50), 1/3rd and 1/10th LC50 concentrations of chlorpyrifos at 15, 30 and 45 days of exposure was carried out in the sensitive organs such as liver. An alteration in the Acid phosphatase (ACP), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and Adenosine triphosphatase enzyme (ATPase) was carried out. The enzyme ACP, ALP and LDH was elevated throughout the experimented period and the ATPase activity was inhibited along the experimental period at three different concentrations of chlorpyrifos.

Authors and Affiliations

Neelam Sharma

Keywords

Related Articles

A clinical study of benign breast diseases attending to government general hospital anantapurmu

About 50-55% of women suffer from some sort of breast disorders in their life time. Benign breast disease is 4-5 times more common that breast malignancy. The current prospective study is carried out to assess study of...

Opinion and suggestions of undergraduate medical students on current teaching methods in pharmacology - A questionnaire based study

Background Pharmacology, like any other branch of medicine, is progressing by leaps and bounds. It is generally agreed that reviewing the teaching program at regular intervals, and modifications in the methodologies of i...

Design formulation and evaluation of gastroretentive floating tablets of stavudine

The purpose of the present research work was to design, formulate and evaluate the floating tablets of Stavudine, a gastro retentive drug delivery system. Direct compression was used to prepare the tablets using HPMC K4M...

Looking Swabhawaparambada through Modern Point of view

In Ayurveda a special emphasis has been given to the concept of Swabhawaparambada (Natural Destruction). Swabhawaparambada has been described in 16th chapter of Charka Sutrasthana that is “Chikitsaprabhritiya adhyaya”....

Retrospective study of cutaneous adverse drug reactions reported at adverse drug reaction monitoring centre (AMC) at GMC/GGH, Guntur, Andhra - Pradesh, India

Background One of the most common manifestation of adverse drug reactions is cutaneous adverse drug reaction, which includes skin and it's appendages, mucous membranes, occurring with a wide variation in morphological p...

Download PDF file
  • EP ID EP411342
  • DOI -
  • Views 115
  • Downloads 0

How To Cite

Neelam Sharma (2014). Assessment of the changes in some diagnostics enzymes in fish Gambusia affinis treated with pesticide chlorpyrifos. International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP), 3(3), 205-210. https://europub.co.uk/articles/-A-411342