Design formulation and evaluation of gastroretentive floating tablets of stavudine
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 1
Abstract
The purpose of the present research work was to design, formulate and evaluate the floating tablets of Stavudine, a gastro retentive drug delivery system. Direct compression was used to prepare the tablets using HPMC K4M, HPMC K15M and Carbopol 974(p) as polymers. Formulations were prepared by varying the amount of polymers. The compatibility of drug with the polymers is identified by using FTIR studies. Gastric floating of Stavudine tablets results from effervescence produced by the reaction between sodium bicarbonate and hydrochloric acid in stomach. Twelve formulations of floating tablets were prepared using direct compression technique with polymer such as carbopol974 (p), HPMC grades, Xanthium gum, Guar gum, chitosan in different ratios. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and buoyancy. Out of all the formulation developed, formulation F8 containing of Carbopol showed in vitro drug release of 97.8% up to desired time period of i.e., 24 hours. Thus it is summarized; carbopol grades can be used in formulation of gastro retentive floating drug delivery system. The compatibility of drug with polymers is identified by FT-IR studies. The results obtained showed that the drug is compatible with all the polymers used. The prepared tablets (F1-F12) were evaluated for both pre-compression and post-compression parameters. The results obtained showed that the drug is compatible with all the polymers used.
Authors and Affiliations
Mourya Adarsh
Keywords
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