Assessment of the relationship between insulin resistance, atherogenic index of plasma and white blood cell count: A data mining study
Journal Title: Cumhuriyet Medical Journal - Year 2017, Vol 39, Issue 2
Abstract
Objective: The hyperinsulinemic-euglycemic clamp tests considered as a gold standard method for assessing the insulin sensitivity, whereas the application of this test in large groups is both difficult and not practical, therefore clinicians need calculating parameters to evaluate the insulin sensitivity. In the study we evaluated the prediction of insulin resistance (IR) by atherogenic index of plasma (AIP) and WBC count. Method: We retrospectively reviewed the records of 139.934 individuals admitted to our hospital from March 2015 to March 2016. 474 individuals were enrolled in our study. Study population’s records such as age, gender, white blood cell (WBC) count and the concentrations of overnight fasting blood glucose, triglyceride (TG), total cholesterol (TCHOL), HDL-C, low density lipoprotein cholesterol (LDL-C) and insulin were recorded from our hospital information system. Results: The receiver operating characteristic curves (AUC) of AIP for predicting IR were 0.670 and 0.690 as measured by homeostatic model assessment-insulin resistance (HOMA-IR) and insulin sensitivity check index (QUICKI), respectively. The area under the curve (AUC) values for predicting IR with WBC count were 0.649 and 0.652 as measured by HOMA-IR and QUICKI, respectively. Conlusions: Negative predictive values of AIP and WBC were found higher than positive predictive values as measured HOMA-IR. AIP and WBC may not serve as a predictor of IR lonely but these markers might be used as surrogate markers may contribute to excluding IR when used in combination with HOMA-IR and QUICKI.
Authors and Affiliations
Halef Okan Doğan, Gülhan Duman
Keywords
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- EP ID EP238822
- DOI 10.7197/223.v39i29491.316368
- Views 81
- Downloads 0
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