Assessment of Three Inflammatory Markers of Cardiovascular Diseases with a Special Accent on C-Reactive Protein
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2018, Vol 4, Issue 2
Abstract
Background: Elevated levels of CRP, myoglobin and creatine kinase are always associated with pathological changes and hence their values give useful information for exact diagnosis and therapy. They are helpful in monitoring the inflammatory processes and associated diseases. Aim: The aim of this study was to determine the usefulness and practical value of application of CRP detection by comparing it with the results obtained for the classical enzymes – markers of myocardial damage, myoglobin and creatine kinase isoenzyme MB (CK-MB) in pts with acute coronary syndrome (ACS), pts with chronic coronary artery disease (CAD) and in healthy individuals. Material and Methods: Sera were taken from a total of 152 individuals (78.9% males, 21.1% females, mean age 61.87 ± 10.32 years). The subjects were divided in three groups: 63 pts with ACS; 52 pts CAD and a group of 36 conditionally healthy individuals. Analysis of patients’ sera for presence of markers for myocardial damage: myoglobin, CK-MB along with determination of CRP level was done on the Immulite system, DPC (Diagnostic Products Corporation), Los Angeles, USA. Results: Comparison of examined biomarker’s values in pts divided according to diagnosis showed statistically significant higher levels in patients with ACS vs. others. As for biomarker’s cut-off values, out of all CK-MB ≥ 5.7 ng/mL was found in 34 (53.1%) pts with ACS with significant difference among the groups in favor of its higher values in pts with ACS (p=0.0001). Out of all, myoglobin ≥ 25 ng/mL was found in 54 (84.4%) pts with ACS without significant difference among the groups. As for CRP, value of ≥ 3 mg/L was found in 39 (60.9%) pts with ACS and there was significant difference among the groups in favor of higher values in pts with ACS (p=0.001). There was significant positive correlation among the levels of examined three biomarkers: CK-MB in correlation to myoglobin (r=0.460; p= 0.0001) and to CRP level (r=0.204; p= 0.009), as well as myoglobin to CRP level (r=0.218; p= 0.005). Conclusion: We could conclude that determination of CRP levels is a valid test for detection of acute coronary artery disease in addition to the classical, standard markers for myocardial damage.
Authors and Affiliations
Tatjana Grdanoska| Institute of Microbiology and Parasitology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Planinka Zafirovska| University Clinic of Cardiology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Branko Jaglikovski| AVICENA Laboratory, Skopje, Republic of Macedonia, Jasmina Trojacanec| Institute of Pharmacology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Dimce Zafirov| Institute of Pharmacology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Dejan Neshov| Institute of Microbiology and Parasitology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Milena Petrovska| Institute of Microbiology and Parasitology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Zhaklina Cekovska| Institute of Microbiology and Parasitology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia, Nikola Panovski| Institute of Microbiology and Parasitology, Faculty of Medicine, University “Ss Cyril and Methodius”, Skopje, Republic of Macedonia
Keywords
Related Articles
- EP ID EP8797
- DOI 10.3889/MJMS.1857-5773.2011.0169
- Views 305
- Downloads 17
Semantic Analysis of Macedonian Medical Abstracts Indexed in the PubMed Database using GoPubMed
Aim: The aim of this study was to analyze semantically medical abstracts from the Republic of Macedonia indexed in the PubMed database with GoPubMed. Material and Methods: The analysis was performed with GoPubMed on Ma...
Efficacy of the Carotid Endarterectomy in Asymptomatic and Symptomatic Carotid Stenosis and in Patients with Multifocal Atherosclerosis
Aim. The aim of the research was to study the effect of carotid endarterectomy (CEA) at patients with asymptomatic and symptomatic carotid stenosis, also in the patients with multifocal atherosclerosis (MFA): carotid s...
Carotid Artery Wall Changes as a Prognostic Indicator of Coronary Artery Disease
Aim. The aim of this study is to investigate the prevalence of coronary and carotid arteries atherosclerotic abnormalities, and exactly to examine the predictive value of ultrasonography of carotid artery on the basis...
Antioxidant Effects of Nigella Sativa in the Treatment of Experimentally Induced Rhinosinusitis
Aim. The objective of this study was to investigate the effect of Nigella sativa (NS) in experimental bacterial rhinosinusitis. Material and Methods. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rab...
Zdravko Trojacanec. Prevention of Sports Injuries. Skopje: Trojacanec; 2009. 151 pages; ISBN 978-9989-3-2; price MKD 300
Field of medicine: Prevention medicine. Audience: Sports medicine specialists, general practitioners, students in medicine. Purpose: Every mental activity of an individual is closely related and dependable on their ph...