Association between Dental Agenesis and Cancer-A Systematic Review of Literature
Journal Title: Open Access Journal of Dental Sciences - Year 2019, Vol 4, Issue 3
Abstract
Cancer is a heterogeneous disease with clinical and etiological diversity. Teeth are formed from neural crest-derived mesenchyme and epithelium of the first branchial arch and part of the frontonasal process. Dental agenesis is characterized by congenital absence of teeth, affecting approximately 5% to 7% of the population, being more prevalent in the permanent dentition. Some types of cancers such colorectal, ovarian, lung and breast are described as containing association with dental agenesis, having induction factors in association where the mutation in some genes functions as these induction factors for the two pathologies. Through the model of the PRISMA review platform, literature databases were analyzed, where keywords of association of dental agenesis and cancer were used. We found 151 articles that made the association, but only 7 specifically met the search requirements. Some genes such as AXIN2, EDA, FGF3, FGFR2, FGFR10, MSX1 and PAX9 are directly associated with dental agenesis and cancers, such as colorectal, ovarian, lung and breast, since the inactivation of some of them also acts as an induction factor in the developmental predisposition neoplastic. More genetic studies are needed to prove the association between dental agenesis and other types of cancers. However, it is observed that people with dental agenesis already have pre-established genetic alterations, which acts as a facilitator of the development of cancer.
Authors and Affiliations
Rodrigo Soares de Andrade
Keywords
Related Articles
- EP ID EP562147
- DOI 10.23880/oajds-16000226
- Views 91
- Downloads 0
Minimal Invasive Single Papilla Sling Suture Technique
Suture techniques are essential parts of flap operations, and different suture techniques are used for different purposes. This paper describes a new suture technique for suturing a flap rised on one surface and involvin...
The Use of Botox Injection to Treat Cerebral Palsy in Children
1.1. Background: Cerebral Palsy is the most common neuromuscular disability in children. It is a group of permanent disorders related to development of movement and posture that occurs in the infant’s brain. Cerebral Pal...
Marginal Adaptation, Fracture Resistance and Failure Patterns of Two CAD/CAM Overlays
Statement of problem Coronal rehabilitation of endodontically treated posterior teeth is still a controversial issue. Purpose: The purpose of this study was to investigate marginal adaptation, fracture resistance and fai...
Effect of Olea Extracts on Oral Candida in Patients Wearing Dentures of Different Base Materials
Background: Through the last recent years many researches started to investigate the properties of Aloe vera. Aloe vera proved to have wide ranges of activities in different fields of medicine. Objective: The study was c...
Wear of the Implant Connection with Zirconia and Titanium Abutments
Background: Classify and quantify the wear of the implant and abutment interface simulating a loose screw situation. Methods: Nine external connection titanium implants were split into 4 groups: Group A (no hexagon titan...