Association between NFKB1 (-94 ins/del ATTG) gene polymorphism and Multiple Sclerosis in the Turkish Population
Journal Title: Advance Research Journal of Multidisciplinary Discoveries - Year 2018, Vol 29, Issue 29
Abstract
Multiple sclerosis (MS) is a chronic inflammatory and an autoimmune disease affecting the central nervous system (CNS). It is suggested that the NFκB signaling pathway is involved in MS development and that NFκB is a key transcription factor involved in the regulation of immune response, apoptosis and pathology of autoimmune diseases. A recently discovered promoter polymorphism in NFKB1 (-94 insertion/deletion ATTG) gene may be associated with MS development.The purpose of this study was to reveal the relationship between NFKB1 -94 insertion/deletion ATTG polymorphism and MS in a Turkish population. A total of 379 patients with MS and 214 healthy individuals from the Turkish population were investigated. The promoter region of NFKB1 gene was amplified DNAs from patients and controls by specific primers and their PCR products were digested by suitable enzyme.NFKB1 (-94 ins/del ATTG) genotype distribution showed a strong association with MS (p=0.0001), and the NFKB1 (-94 ins /del ATTG) allele frequency also showed a significant association to the disease (p = 0.011).Our results suggested that the NFKB1 -94 ins/del ATTG gene promoter polymorphism is associated with MS in the Turkish population.
Authors and Affiliations
Arman A, Erzaim N, Isik N, Saridal M, Hoscan AY, List EO
Keywords
Related Articles
- EP ID EP397310
- DOI -
- Views 61
- Downloads 0
Curriculum, competences and intercultural education : New approach to the curriculum
Curriculum development is a problem solving process and it involves the consideration of the needs and problems for the improvement of the programs and the implementation of solutions and alternatives for learners and th...
A STUDY ON HUMANISM IN TELUGU LITERATURE AMONG INTERMEDIATE STUDENTS IN KURNOOL TOWN (A.P)
The purpose of the study is to know the knowledge of Humanism in Telugu literature among Intermediate students in Kurnool Town. The Investigator conducted data collection of 140 samples by using simple Random sampling me...
“Rice (Oryza Sativa) cultivation in temperature areas of India”
ice botanically called as Oryza Sativa, is associated with wet, humid climate, though it is not a tropical plant. It is probably a descendent of wild grass that was most likely cultivated in the foothills of the far East...
Nursing Students Perceptions and Knowledge Regarding Patient Safety.
Objectives: Patient safety is an important component of patient care that emphasizing incident management and risk reduction strategies. The present exploratory study aimed to explore Saudi nursing students‟ knowledge an...
INTERNAL MARKETING AND SERVICE QUALITY IN SELECTED INSURANCE FIRMS IN SOUTH – EAST, NIGERIA
This paper examined Internal Marketing and Service Quality in Selected Insurance Firms in South-East, Nigeria. The design for the study was the survey research and it covered a population of 109 members of staff of six s...