ASSOCIATION BETWEEN PERIODONTAL DISEASE AND HEAD AND NECK CANCER AND ESTIMATION OF C -REACTIVE PROTEIN: A CLINICAL AND BIOCHEMICAL STUDY
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 2
Abstract
Background: Moderately elevated serum C-reactive protein (CRP) concentration is a systemic marker of inflammation and a documented risk factor for head and neck cancer. Unrecognized infections, such as periodontal disease, may induce an acute-phase response, elevating CRP levels. Objectives: The objective of this study was to associate the Periodontal status and serum C – reactive protein level with Head and neck cancer patients and systemically healthy chronic periodontitis patients. Methods: Thirty individuals; 15 diagnosed with head and neck cancer and 15 systemically healthy patients with chronic periodontitis were analyzed. The periodontal evaluation was done using clinical attachment level (CAL), probing depth (PD) and gingival index (GI). Serum CRP was quantified in milligrams per liter using an Immunostat C – Reactive protein kit. Results: There is a significant increase in the GI, PD CAL and CRP in the Head and neck cancer patients as compared to the chronic periodontitis cases (P <0.05). Serum CRP concentration was positively correlated with mean GI (P<0.001), mean PD (P<0.001) and mean CAL (P<0.001). Conclusion: This study suggests a positive association between periodontal disease and serum CRP concentration in patients with head and neck cancer. However, more longitudinal studies are necessary to determine the exact causal relationship between serum CRP concentration and chronic periodontitis.
Authors and Affiliations
Safat Sadiq, Rahul Bhandary
Keywords
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