Association between polychlorinated biphenyls in the serum and adipose tissue with type 2 diabetes mellitus: A systematic review and meta-analysis
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 9
Abstract
Prevalence of diabetes, especially type 2 diabetes is increasing. One of the environmental risk factors of this disease is persistent organic pollutants. Studies have obtained different results in the field of association of different congeners of persistent organic pollutants such as polychlorinated biphenyls with type 2 diabetes. In this review study (systematic review and meta-analysis), the authors aimed to evaluate the association of different congeners of polychlorinated biphenyls with type 2 diabetes in both prospective and cross-sectional studies. After a systematic review, 6 prospective and 9 cross-sectional studies were evaluated. Mean of odds ratio and heterogeneity for all the studies were OR=1.97; CI (1.57-2.39) and I2=42.9%; Ïheterogeneity=0.009, respectively. Also, mean of odds ratio for the prospective studies (OR=1.59; CI(1.29-1.95); I2=2.37%; Ïheterogeneity=0.42) was less than that of the crosssectional studies (OR=2.4; CI (1.71-3.36); I2=49.8%; Ïheterogeneity= 0.025). Increase in different congeners of PCBs in the serum and adipose tissue can significantly increase the prevalence type 2 diabetes (p value<0.001). This study supports a positive association of polychlorinated biphenyls in the serum and adipose tissue with type 2 diabetes.
Authors and Affiliations
Vajihe Hassanzadeh| Food and Cosmetic Health Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran, Mohammad Hadi Mehdinejad| Environmental Health Research Center, Golstan University of Medical Sciences, Golstan, Iran, Margherita Ferrante| Environmental and Food Hygiene Laboratories (LIAA), ‘G.F. Ingrassia’ Department, Hygiene and Public Health, University of Catania, Catania, Italy, Hassan Keramati| Department of environmental Health Engineering, School of Public Health, Semnan University of Medical Sciences, Semnan, Iran, Yahya Zandsalimi| Environmental Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran, Bigard Moradi| Department of Health Public, Kermanshah University of Medical Sciences, Kermanshah, Iran, Leila Rasouli Amirhajeloo| Department of Environmental Health Engineering, School of Public Health, Qom University of Medical Sciences, Qom, Iran, Yadolah Fakhri| Student research office, Department of Environmental Health Engineering, School of Public Health, Shahid Beheshti University of Medical sciences, Tehran, Iran, Abotaleb Bay| Environmental Health Research Center, Golstan University of Medical Sciences, Golstan, Iran, Corresponding Email: abotaleb_bay@yahoo.com
Keywords
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