Serum Level of Interleukin-18 to Interleukin-10 Ratio after Percutaneous Coronary Intervention: A New Predictor of In-Stent Restenosis
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 10
Abstract
Despite advanced techniques of stent placement which cause fewer traumas to the vessel walls; as well as introduction of drug-eluting stents which result in the least induction of immune response, in-stent restenosis (ISR) is still one of the common and severe complications after PCI and stent placement. Intimal hyperplasia following immuno- inflammatory response of the arterial wall to balloon injury has been proposed as main mechanism of ISR. In a prospective study, we assessed the predictive role of Interleukin (IL)-18 and tumor necrosis factor alpha (TNF- α) as pro-inflammatory cytokines and IL-10 as anti-inflammatory cytokine and high sensitive C-reactive protein (hsCRP) for ISR. 128 patients (mean age=59±10.2, femal e/male: 41/87)who underwent percutaneous coronary intervention (PCI) and stent implantation. Venous blood samples were obtained before and 24 hours after PCI. IL- 18, IL-10, TNF-αand hs-CRP levels were determined. We followed the patients for24months and measured the incidence of ISR via angiography. Results were compared between ISR and non-ISR patients. 20 patients (15.6%) developed ISR. Serum level of IL-18, TNF-α and hs-CRP have been increased in all patients 24 hours after PCI. Serum level of IL-18 at 24-hours was not different between ISR and non-ISR patients (p=0.239), while serum level of IL-10 was significantly higher in non-ISR group (p<0.001). IL-18/IL-10 was significantly higher in ISR patients than in non-ISR patients (p<0.001). IL-18/IL-10 can be applied as predictive factors for ISR.
Authors and Affiliations
Nozar Givtaj| Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran, Hossein Ali Bassiri| Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran, Mohammad Mehdi Peighambari| Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran, Corresponding E-mail:mehdipei@gmail.com, Feridoun Noohi| Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran, Hooman Bakhshandeh| Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Keywords
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