Association between Serum Malondialdehyde and Insulin in Type 2 Diabetes Mellitus in Eastern India
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Objectives: Oxidative stress and insulin plays a pivotal role in the pathogenesis of type 2 diabetes mellitus (T2DM). The aim of our study was to study the altered levels of serum insulin and malondialdehyde and putatively establish their association in T2DM individuals. Methods: The preliminary case-control study included age, sex and body mass index (BMI) matched 56 T2DM cases and 42 healthy control subjects. Serum MDA was measured using a spectrophotometer while fasting serum levels of insulin was measured by commercially available immunoassay kits as well as routine biochemical parameters were analyzed in all study and control subjects. Results: Serum MDA level was observed significantly higher among T2DM subjects with respect to controls (p < 0.0001). An increase in serum insulin levels were also found in T2DM cases as compared to controls and were statistically significant (p < 0.0001). Further, serum MDA level showed a significant weak positive correlation with fasting plasma insulin (r = 0.265; P = 0.047) level among T2DM subjects, but no significant correlation was observed in controls (r = 0.114; P = 0.471). Conclusion: The association between serum MDA and insulin suggests that it may be used as a prognostic marker for the pathogenesis of T2DM
Authors and Affiliations
Dr Vineet Kumar Khemka
Keywords
Related Articles
- EP ID EP285159
- DOI -
- Views 56
- Downloads 0
Socio-demographic correlates of HIV-TB Co-infected Patients Attending ART Centre of Jharkhand
Background: The HIV epidemic has posed a major challenge to control tuberculosis (TB) across the world. HIV and TB both primarily affect people in their most productive years of life. Objectives: This study was done aimi...
A prospective study to evaluate the incidence of Palmoplantar Psoriasis in North Region of India
Background: Psoriasis is a common and chronic T cell mediated skin disorder with varied clinicomorphological types. Most of the published studies have reported chronic plaque type psoriasis to be the commonest type. Aim...
To predict the risk of early onset sepsis in relation to duration of Premature rupture of membrane
Introduction: India has one of the highest infant mortality rate in the world. Early onset septicemia (EOS) is one of the leading cause for high IMR. Duration of PROM is important risk factor for EOS in neonates. Present...
Risk Factors of Recerrunt Acute Pancreatitis
Acute Pancreatitis is one of the acute surgical condition .It is one of most important differential diagnosis to be considered. The aetiology of pancreatitis is different. Gall stones, alcohol, trauma to abdomen drugs, m...
Effectiveness of Epley’s Manoeuvre in Benign Paroxysmal Positional Vertigo- A Prospective Study
Introduction: Benign Paroxysmal Positional Vertigo (BPPV) is one of the most common causes of vertigo. The patient complains of brief but severe episodes of rotatory vertigo lasting less than a minute upon sudden changes...