Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 5
Abstract
Background: This study examined the significant association between carbamazepine (CBZ)-induced Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and HLA-B*15:02 in epilepsy patients of Han ethnicity living in northeastern China. Methods: CBZ-SJS/TEN patients and CBZ-tolerant control patients were genotyped for HLA-B*15:02 by PCR amplification using sequence-specific primers. Patients then were evaluated for HLA genotypes using PCR with sequence-based typing. Results: Eight of 35 CBZ-SJS/TEN patients carried HLA-B*15:02 (22.9%) versus 2 of 125 in CBZ-tolerant control patients (OR = 18.222, 95% CI = 3.662-90.662, p = 0.000). Our results suggest that HLA-B*15:02 is necessary but is not sufficient to produce SJS/TEN following CBZ treatment among Han individuals from northeastern China. Other HLA alleles, including A*33:03, B*58:01, C*03:02, DQB1*03:03, and DRB1*07:01 may be associated weakly with CBZ-SJS/TEN. Conclusions: Our results are not consistent with previous studies reporting a strong association between HLA-B*15:02 and CBZ-SJS/TEN among individuals from southern, southwestern, and central China. Other genes may be more tightly associated with CBZ-SJS/TEN. Screening for HLA-B*15:02 still may be recommended for patients in northeastern China before starting CBZ.
Authors and Affiliations
Xiao-Jing He, Ling-Yan Jian, Xiao-Lin He, Yan Wu, Yuan-Yuan Xu, Xiao-Jie Sun, Li-Yan Miao, Li-Mei Zhao
Keywords
Related Articles
- EP ID EP126136
- DOI -
- Views 81
- Downloads 0
Abstracts of The Fifteenth Days of Neuropsychopharmacology. UstroĊ-Jaszowiec, May 29-31, 2006.
Synthesis, anticonvulsant properties and 5-HT1A/5-HT2A receptor affinity of new N-[(4-arylpiperazin-1-yl)-propyl]-2-aza-spiro[4.4]nonane and [4.5]decane-1,3-dione derivatives.
A series of twenty new N-[(4-arylpiperazin-1-yl)-propyl]-2-aza-spiro[4.4]nonane- and [4.5]decane-1,3-dione derivatives were synthesized and their anticonvulsant activity was evaluated in maximal electroshock (MES) and sc...
Neuroprotective potential of three neuropeptides PACAP, VIP and PHI.
Pituitary adenylate cyclase activating polypeptide (PACAP), vasoactiveintestinal peptide (VIP) and peptide histidine-isoleucine (PHI), are structurally related endogenouspeptides widely expressed in the central and perip...
Effects of 3-aminopyridine-induced seizures on platelet eicosanoid synthesis.
We investigated the influence of recurrent epileptic seizures on the arachidonic acid (AA) cascade in platelets and brain microvessels, using [(14)C]AA as a tracer substrate and chromatographic determination. The recurre...
Dual effects of heparin on BMP-2-induced osteogenic activity in MC3T3-E1 cells.
Heparin displays several types of biological activities by binding to various extracellular molecules, including pivotal roles in bone metabolism. We have previously reported that heparin competitively inhibits the bindi...