Coronary microvascular dysfunction and idiopathic dilated cardiomyopathy.
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue
Abstract
There is growing evidence of the presence and relevance of coronary microvascular abnormalities in many cardiac diseases. In particular, it has been recently shown that dilated cardiomyopathy(DCM) is characterized by dysfunction of the coronary microvessels since its very early onset. Coronary microcirculatory dysfunction is not an effect of myocardial damage but seems in turn to cause progressive contractile impairment, ventricular dilation and heart failure. The mechanisms of the progressive deterioration of cardiac function in DCM are largely unknown but both myocardial hypoperfusion and myocardial ischemia at the microvascular level are most probably involved. It has been demonstrated that the presence and the extent of coronary microcirculatory dysfunction in patients with early stage DCM is an independent and relevant predictor of worse prognosis. From these studies it is more and more evident that the coronary microcirculation is involved in the pathogenesis of DCM and should be considered a new target of treatment in those cardiac diseases at risk to evolve towards heart failure.
Authors and Affiliations
Danilo Neglia, Antonio L'Abbate
Keywords
Related Articles
- EP ID EP101935
- DOI -
- Views 116
- Downloads 0
Yohimbine-induced alterations in alpha(2)-adrenoceptors in kidney regions of the spontaneously hypertensive rats: an autoradiographic analysis.
We have tested the hypothesis that a pharmacologically determined alteration in renal alpha(2)-adrenoceptor (alpha(2)-AR) density might be a pathophysiologically important factor of genetic hypertension in the spontaneou...
Primary and secondary clarithromycin, metronidazole, amoxicillin and levofloxacin resistance to Helicobacter pylori in southern Poland.
The aim of this study was to assess the primary and secondary resistance of H. pylori strains cultured from adult patients of the Małopolska region of Poland, mainly of Kraków and the surrounding areas, to antibacterial...
Effects of standard heparin and low-molecular-weight heparins on the formation of murine osteoclasts in vitro.
Long-term administration of heparin can lead to development of osteoporosis. The aim of the present study was to examine the effects of standard heparin and low-molecular-weight heparins (nadroparin, enoxaparin, parnapar...
Association between the HLA-B*15:02 allele and carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Han individuals of northeastern China.
Background: This study examined the significant association between carbamazepine (CBZ)-induced Stevens-Johnson Syndrome (SJS)/toxic epidermal necrolysis (TEN) and HLA-B*15:02 in epilepsy patients of Han ethnicity living...
Deposition of ethyl glucuronide in WHP rat hair after chronic ethanol intake.
Background: This study investigated the relationship between ethanol intake in rats and the resulting level of ethyl glucuronide (EtG) in rat hair. Methods: Rats (n = 50) consumed a 10% ethanol solution for 4 weeks, then...