Association between trigeminal neuralgia and multiple sclerosis in Iranian patients: A systematic Review and meta-analysis
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 12
Abstract
Introduction: Multiple sclerosis (MS) is a chronic neuro-inflammatory disease of central nervous system (CNS) which is characterized by variable evolution and different clinical manifestations. Although pain is one of the most common problems of MS patients, the presence of trigeminal neuralgia (TN) in a patient's life-span is rare. Considering that trigeminal neuralgia is one of the symptoms of the onset of MS, this systematic review and meta-analysis was conducted to determine the prevalence of Trigeminal neuralgia in Iranian MS patients. Methods: The methods used for this systematic review were based on the "Cochrane Systematic Study Booklet" and "Appropriate Items for Systematic review and Meta-Analysis Study (PRISMA)" tool. Observational studies conducted on general population have been added and studies conducted on specific population have been removed. Results are summarized as reported in the research. The minimum sample size was 25 patients in each study. To find references, the international Databases (MEDLINE PubMed interface), Google Scholar, and Web of Science) and domestic databases (SIDs and Magiran) and journals were searched; unlimited searching, in terms of both setting and language, was done until June 30, 2018. Results: In the initial search on various databases, a total of 461 articles were reviewed, 432 of which turned out to be repetitive during screening process of title and abstract. 19 articles were removed due to unrelated title; out of the remaining 10 articles, 5 articles met the inclusion criteria.Based on the results of random effects model, the Prevalence of trigeminal neuralgia in Iranian multiple sclerosis patients in 2273 patients was %05.8 (95% confidence interval [CI]: 4.9, 6.7, I2 = 88%). Conclusion: The prevalence of trigeminal neuralgia in patients with multiple sclerosis turned out to be 5.8% in the present study. This issue highlights the need for physicians to be aware of the causes of facial atypical pain, including triple-nerve pain, especially in patients under 40 years of age. Adequate knowledge and timely diagnosis of trigeminal neuralgia, as the first symptom of MS disease, can help physicians diagnose the disease timely; in case of positive diagnosis, the physicians can start treatments rapidly, avoiding the use of inappropriate and unnecessary therapies.
Authors and Affiliations
Khosro Jamebozorgi
Keywords
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- EP ID EP548957
- DOI 10.22192/ijcrms.2018.04.12.005
- Views 254
- Downloads 0
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