Association between urine albumin creatinine ratio and high sensitivity C-reactive protein in patients with type 2 diabetes mellitus
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction Diabetes mellitus is one of the leading causes of morbidity and mortality for its association with complications like nephropathy neuropathy retinopathy and cardiovascular diseases Chronic inflammation plays an important role in the development and progression of late complications of diabetes and diabetic nephropathy DN is one of the major longterm complications of diabetes mellitusAims and Objectives To determine serum high sensitivity Creactive protein hsCRP and urine albumin creatinine ratio UACR in patients with type 2 DM and to evaluate the relationship of hsCRP with UACR as markers of early kidney damageMaterials and Methods Cross sectional study which included 95 clinically diagnosed type 2 DM patients of age group 40 to 70 years Spot urine microalbumin and creatinine were estimated by immunoturbidimetry and Jaffe method respectively and the results were reported as albumin creatinine ratio mgg The patients were divided into two groups diabetic with microalbuminuria as cases and without microalbuminuria as controls hsCRP was estimated by immunonephelometry method Statistical analysis was done using SPSS 200 Data were analysed using student t test for their level of significance Correlation between variables was carried out using the Pearson correlation coefficientResults The mean hsCRP was higher in diabetic patients with microalbuminuria 728 346 comparing to diabetic patients without microalbuminuria 104 085 and was statistically significant pConclusion Microalbuminuria was accompanied by elevated hsCRP level suggesting activation of inflammatory pathways in development of kidney disease So as a screening method measurement of serum hsCRP along with urine albumin creatinine ratio helps in diagnosing early stages of diabetic nephropathyKeywords Type 2 DM High sensitivity Creactive protein Urine albumin creatinine ratio Diabetic nephropathy
Authors and Affiliations
Sujesh Kumar N, Sajitha Krishnan
Keywords
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- EP ID EP475185
- DOI 10.18231/2394-6377.2018.0081
- Views 84
- Downloads 0
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