Association between VDR Gene Polymorphisms (<i>rs 1544410</i>, <i>rs 7975232</i>, <i>rs 2228570</i>, <i>rs 731236</i> and <i>rs 11568820</i>) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population
Journal Title: International Journal of Cancer Management - Year 2017, Vol 10, Issue 3
Abstract
Background Vitamin D receptor (VDR) is a key nuclear receptor that is associated with the risk and progression of breast cancer (BC). Objectives The present study investigated the <i>Fok1</i>, <i>Bsm1</i>, <i>Taq1</i> and <i>Cdx2</i> polymorphisms in the VDR gene and susceptibility to BC in a sample of Southeastern Iranian population. Methods This case-control study was conducted on 180 women with BC and 178 age-matched healthy women. RFLP-PCR method was used for analysis of <i>Bsm1</i> (<i>rs 1544410</i>), <i>Apa1</i> (<i>rs 7975232</i>), <i>Fok1</i> (<i>rs 2228570</i>) and <i>Taq1</i> (<i>rs 731236</i>) and also TETRA-ARMS method for <i>Cdx2</i> (<i>rs 11568820</i>). Results No significant correlation was found between polymorphisms of <i>Taq1</i>, <i>Fok1</i> and Apa1 with BC, but was for <i>Bsm1</i> (odds ratio (OR) = 3.452, 95% CI 1.769 - 6.738; P < 0.001). Also, there was a significant correlation between the case and control groups for <i>Cdx2</i> (OR = 3.720, 95% CI 2.224 - 6.225; P < 0.001) and allele A in <i>Cdx2</i> had just significant correlation with BC. Conclusions The present study findings showed that there were significant correlations between <i>Bsm1</i> and <i>Cdx2</i> polymorphisms with BC in women of Sistan and Baluchestan Province (southeastern Iran). Also, signals of <i>Rs1544410-Bsm1</i> and <i>Rs11568820-Cdx2</i> positions were difference with routes of estrogen and progesterone per person and they probably act independently.
Authors and Affiliations
Seyed Mehdi Hashemi, Narges Arbabi, Mohammad Hashemi, Mohammad Ali Mashhadi, Abolghasem Allahyari, Masoud Sadeghi
Keywords
Related Articles
- EP ID EP237330
- DOI 10.5812/ijcm.8807
- Views 57
- Downloads 0
Association Between NAT2 Polymorphisms and Prostate Cancer
Background NAT2 enzyme involved in bioconversion of aromatic amines, heterocyclic arylamines and certain drugs into electrophilic ions that can be important initiators in tumorige...
Comparison of Surgical Margin After Breast Cancer Surgery Between Oncoplastic Technique and Conventional Breast-Conserving Surgery
Background: Compared to other breast surgery methods, the accurate determination of pathologic margin in oncoplastic technique can affect its development and further employment of this technique. The current study aimed...
Co-Administration of Anti-Angiogenic Peptide and DNA Vaccine in Cervical Cancer Tumor Model
Background Cervical cancer is one of the main causes of women’s death in the world. Human papilloma virus (HPV) types 16 and 18 have been known as a cause of more than 2/3 of cerv...
Anti-Proliferative Effects of Piroxicam and Nimesulide on A431 Human Squamous Carcinoma Cell Line
Background Skin cancer is one of the most common types of cancer worldwide and non-steroidal anti-inflammatory drugs (NSAIDs) have been proposed for prevention and treatment of a...
Positive Peritoneal Cytology as a Predictor of Prognosis in Early Stage of Endometrioid Adenocarcinoma
Background Peritoneal cytology has been reported to be an independent risk factor for poor survival, but it is not included in the current international federation of gynecology a...