Association of Adiponectin with Components of Metabolic Syndrome in Western U.P.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 12
Abstract
Introduction: Obesity is common and unequivocally associated with several serious complications as Metabolic Syndrome (MetS). Despite considering obesity as a defaulter in reducing life expectancy, an exponential weight gain from one generation to the next is not inevitable. According to International Diabetes Federation (IDF), central obesity is a must criterion to define MetS. A number of obesity related peptide hormones have been recognised to play a role in the pathogenesis of MetS. Adiponectin is a recently identified most abundant adipose-tissue derived protein that is potentially anti-atherogenic & anti-inflammatory in nature. Out of all adipokines secreted from adipose tissue, only adiponectin founds to be reduced with increasing obesity. Material Method: Adiponectin (ADI) level varies depending on gender, age & ethnic background therefore we aim to circulate and explore the relation of serum adiponectin with escalating components of MetS in study population of Meerut (U.P) India. It is necessary to find accountability of adiponectin in MetS prior to its implementation in clinical practice. The study was conducted on MetS patients attending OPD of Chhatrapati Shivaji Subharti Hospital, Meerut from December 2016- December 2017. Total of 175 subjects (122 with MetS and 53 non-MetS) were included. Their anthropometric parameters, sugar, Lipid & Adiponectin level were measured. Result: On comparison between controls & the subject of MetS, level of serum adiponectin was significantly lower (p<0.05) in the subjects with MetS. Adiponectin is positively correlated with age, diastolic B.P, cholesterol, HDL & LDL while negatively correlated with BMI, systolic B.P, Fasting glucose, TG & VLDL. Serum adiponectin is decreasing with the increasing number of MetS components being insignificantly higher among females than males (p≥0.05).
Authors and Affiliations
Suryakant Nagtilak.
Keywords
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