Association of Aromatase Gene Polymorphism (rs700518) with Essential Hypertension among midlife women
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2013, Vol 4, Issue 6
Abstract
Hypertension or high blood pressure affects about 26% of adults around the world. It is a main risk factor for stroke, myocardial infarction, angina, kidney failure and heart failure or early death from a cardiovascular cause. We investigated a possible association of a polymorphism (A rs700518) in CYP19A1 gene with hypertension among midlife women. A total of 100 midlife women were enrolled randomly, including 50 hypertension patients and 50 healthy controls. In this study, their blood pressure, weight, height, Triglycerides, blood sugar and cholesterol were measured and their body mass index was calculated. PCR-RFLP for rs700518 polymorphism analysis was used. Genotype frequencies of AA, AG and GG, respectively, 42%, 40% and 18% in hypertensive patients, 22%, 48% and 30% in the control group. Allele frequency of A and G, respectively, were 62% and 38% in hypertensive patients and 46% and 54% in the control group. In this study, selected polymorphism was significantly associated with hypertension. Interestingly, women with hypertension were more likely to be homozygous for the A allele (AA) compared to control cases. We concluded that rs700518 polymorphism in CYP19A1 gene is associated with hypertension in midlife women.
Authors and Affiliations
Shabnam Hemmati-Mazraeh*| Department of Genetics, Islamic Azad University, Ahar Branch, Ahar, Iran. Shabnamhemati1986@yahoo.com, Faegheh Sadeghi| Department of Genetics, Islamic Azad University, Ahar Branch, Ahar, Iran., Majid Farshdousti-Hagh| Department of Pharmaceutical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Keywords
Related Articles
- EP ID EP5491
- DOI -
- Views 314
- Downloads 12
Filter-based Current Sensing with Self-tuning in power electronics Applications for increasing accuracy and decreasing losses
Motor current is used as a control variable in motor drives. Vector control and direct torque control require current sensing for control purposes. Speed sensorless and voltage sensorless control approaches require motor...
Textual Positions of Lexical Bundles across Newspaper Genres
According to Hoey (2005), words or their combinations may be primed to occur or avoid occurring at the beginning or end of independently recognized discourse units, like the sentence and the paragraph; these are their t...
Using Quantum Gates to design a PID Controller for Nano robots
Scientists and engineers are on a mission to generate a robot so small it can fit into a human vein. Such a micro robot could be used to target the cause of an ailment or disease and provide medication directly to the in...
Studying of interaction effect between organic matter and arsenic element on transfer coefficient (TC) in cress plant
This research was done aimed to Studying of Interaction Effect between Organic Matter and Arsenic Element on Transfer Coefficient (TC) in Cress plant. The research was performed in the flowerpot format in a completely ra...
Athletes’ a awareness of dental injuries among different sports in kermanshah, 2014
dental injuries and associated side effects are one of the most important concerns in oral health. Traumatic dental injuries may occur due to several factors, the most important of which is sport. Thus, the current study...