Association of Aromatase Gene Polymorphism (rs700518) with Essential Hypertension among midlife women
Journal Title: International Research Journal of Applied and Basic Sciences - Year 2013, Vol 4, Issue 6
Abstract
Hypertension or high blood pressure affects about 26% of adults around the world. It is a main risk factor for stroke, myocardial infarction, angina, kidney failure and heart failure or early death from a cardiovascular cause. We investigated a possible association of a polymorphism (A rs700518) in CYP19A1 gene with hypertension among midlife women. A total of 100 midlife women were enrolled randomly, including 50 hypertension patients and 50 healthy controls. In this study, their blood pressure, weight, height, Triglycerides, blood sugar and cholesterol were measured and their body mass index was calculated. PCR-RFLP for rs700518 polymorphism analysis was used. Genotype frequencies of AA, AG and GG, respectively, 42%, 40% and 18% in hypertensive patients, 22%, 48% and 30% in the control group. Allele frequency of A and G, respectively, were 62% and 38% in hypertensive patients and 46% and 54% in the control group. In this study, selected polymorphism was significantly associated with hypertension. Interestingly, women with hypertension were more likely to be homozygous for the A allele (AA) compared to control cases. We concluded that rs700518 polymorphism in CYP19A1 gene is associated with hypertension in midlife women.
Authors and Affiliations
Shabnam Hemmati-Mazraeh*| Department of Genetics, Islamic Azad University, Ahar Branch, Ahar, Iran. Shabnamhemati1986@yahoo.com, Faegheh Sadeghi| Department of Genetics, Islamic Azad University, Ahar Branch, Ahar, Iran., Majid Farshdousti-Hagh| Department of Pharmaceutical Biotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
Keywords
Related Articles
- EP ID EP5491
- DOI -
- Views 276
- Downloads 12
Effects of organizational culture, structure and strategy on organizational effectiveness by using knowledge management Case Study: Seven International Transportation Company
Today, one of the most important and valuable assets at any organization is organizational knowledge. Therefore, organizations seek to identify crucial factors and an effectual bed to make knowledge management, and while...
The effect of story books on first language acquisition, between the children of age level 3-4
The words have the power to shape our thoughts, feeling, beliefs, practices and our relations. And have stronger impact when they are put together in a coherent way, such as stories. Stories teach us, and to help us to m...
Shape analysis of common bean (Phaseolus vulgaris L.) seeds using image analysis
Morphological features of common bean (Phaseolus vulgaris L.) seeds were measured in five bean cultivars (Akhtar, Ks21189, Ks31169, G11867 and khomein) using digital image analysis. The images of seeds were captured usin...
Security and Job Stability under the Privatization Process in Iran
Job security is one of the important issues in life of every human being. Economic globalization can lead to changes in working relationships with the increasing development of technology; governments have to adjust econ...
Investigation of Value Relevance of Cash Flows, Current Accruals and Non-current Accruals relative to the Value Relevance of Earnings
Useful information is the base of decisions by people who are participating in the capital market. Determiners of accounting standards try to provide financial reporting and information needs of the accounting systems of...