Association of cerebrospinal fluid colony stimulating factor 1 receptor with cerebrospinal fluid biomarkers and cognition in Alzheimer disease
Journal Title: Chinese Journal of Nervous and Mental Diseases - Year 2025, Vol 51, Issue 2
Abstract
[Objective] To investigate the relationship between cerebrospinal fluid (CSF) colony stimulating factor 1 receptor (CSF1R) and CSF biomarkers of Alzheimer disease (AD), and to analyze whether CSF1R is associated with mild cognitive impairment patients’ cognition. [Methods] Data from non-demented adults were collected from the Alzheimer Disease Neuroimaging Initiative database, and participants were divided into four groups (A-/TN-, A+/TN-, A+/TN+ and A-/TN+), according to the NIA-AA criteria, and the dynamic changes of CSF1R in CSF at different pathological stages of AD were tracked. Multiple linear regression models were used to analyze the relationship between CSF1R and AD biomarkers and cognition, and mediation models were used to investigate the potential association between CSF1R and AD pathology. [Results] A total of 451 non-demented adults were enrolled in this study, and we found that CSF CSF1R levels were increased in the A-/TN+ group (P<0.05) and the A+/TN+ group (P<0.05) compared with the A+/TN- group. CSF CSF1R levels were significantly and positively correlated with CSF tau protein (P<0.001) and phosphorylated tau protein (P<0.001) levels but not with amyloid β-protein (P=0.123), and similar results were obtained in the cognitively normal and mild cognitive impairment groups. In the mild cognitive impairment group, higher CSF CSF1R levels were associated with lower cognitive (P<0.05) levels. Furthermore, the relationship between CSF1R and AD pathology was mediated in part by soluble triggering receptor expressed on myeloid cells 2 (sTREM2) (percentage: 19.3% to 31.4%). [Conclusions] This study is the first study to discover the association of CSFIR with AD biomarkers and cognition, and CSF1R may influence AD pathology through soluble TREM2 (sTREM2).
Authors and Affiliations
Yujing WANG, Yixin XU, Dandan ZHANG, Ji WANG, Yi WANG, Xin WANG
Keywords
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- EP ID EP764332
- DOI 10.3969/j.issn.1002-0152.2025.02.005
- Views 13
- Downloads 0
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