Association of CYP17 Gene Polymorphism with Carcinoma of Prostate
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 8
Abstract
The CYP17 gene encodes for the Cytochrome P450c17ɑ enzymes 17ɑ hydroxylase, 17-20 lyase in testosterone synthesis. There is a polymorphism (T to C substitution) in the 5’ untranslated region of CYP17 gene, providing an increased rate of transcription of CYP17 mRNA, which in turn increases enzyme cytochrome P-450c17 synthesis, increases androgen production and increase cell division in the prostate, thereby increases the risk of carcinoma of prostate. Genotype analysis was done on 50 patients with proven carcinoma of prostate and 50 healthy controls by polymerase chain reaction followed by restriction digestion. Men with A2/A2 CYP17 genotype had an increased risk of carcinoma of prostate with an odds ratio (OR), of 2.13; 95% confidence interval (CI) =1.33-3.51] compared with those with the A1/A1 genotype. The trend of an increasing risk of carcinoma of prostate with an increasing number of A2 allele was statistically significant. The A2 allele of the CYP17 polymorphism is associated with an increased risk of carcinoma of prostate. Keywords:CYP17 gene polymorphism, carcinoma of prostate, restriction digestion
Authors and Affiliations
G. Sasirekha
Keywords
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