Association of estrogen and progesterone with cancer of the uterine cervix in women infected with high-risk human papillomavirus
Journal Title: Journal of Medical and Scientific Research - Year 2018, Vol 6, Issue 1
Abstract
Background: High-risk human papillomavirus (HR-HPV) infection is essential for the development of dysplasia and cervical cancer. Steroid hormones are implicated as risk factors for cervical carcinogenesis. Thus the aim of the present study is to investigate the association of serum levels of estrogen and progesterone with cervical cancer in HR-HPV infected women. Methods and materials: The present study consisted of 103 subjects infected with HR-HPV from low-grade squamous intraepithelial lesion (LSIL) to cervical cancer. They included 37 premenopausal women (luteal phase) and 43 postmenopausal women as cancer cases (high-grade squamous intraepithelial lesion and cervical cancer). Twelve women with LSIL for premenopausal and 11 women with LSIL for postmenopausal were chosen as controls. The concentration of estradiol and progesterone were estimated using enzyme linked immuno sorbent assay kit. The prevalence of HPV infection was expressed as percentage of HPV positives. The data for estradiol and progesterone were expressed as mean ± SD. Results: The serum levels of estradiol were not significantly altered in premenopausal and postmenopausal cases (p>0.05). However, the serum levels of progesterone were significantly increased in premenopausal cases as compared to premenopausal controls (p<0.025). The serum levels of progesterone were not significantly altered in postmenopausal cases (p>0.05). The ratio of estradiol to progesterone was significantly decreased in premenopausal cases (p<0.001) where as it was not significant in postmenopausal cases (p>0.05). Conclusion: A significantly elevated levels of progesterone is associated with cervical cancer in premenopausal women infected with HR-HPV.
Authors and Affiliations
Krishnan Baskaran, Kranthi Kumar P, Santha K, Inmozhi Sivakamasundari
Keywords
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- EP ID EP554281
- DOI 10.17727/JMSR.2018/6-13
- Views 134
- Downloads 0
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