Association of Fructosamine and HbA1c in Newly Diagnosed Type 2 Diabetes Mellitus Patients
Journal Title: Indian Journal of Basic and Applied Medical Research - Year 2018, Vol 7, Issue 2
Abstract
Introduction: Uncontrolled blood sugar is the main culprit for high levels of morbidity and mortality in diabetic patients worldwide. The blood glycated hemoglobin (HbA1c) and fructosamine provide a good picture of average plasma glucose for the previous 2-3 months and 2-3 weeks, respectively. Aim: To associate the HbA1c and Fructosamine in newly diagnosed Type 2 diabetes mellitus (T2DM) patients to find an alternative marker and better predictor for the early development of diabetic complications. Material and Methods: Total 70 subjects (35 T2DM and 35 age and gender-matched healthy controls) were enrolled from the rural and suburban population of North India. Biochemical investigations were performed by commercial kits using Chemistry Auto-analyzer. P<0.05 was considered statistically significant. Result: The mean of fasting blood sugar (FBS), post-prandial blood sugar (PPBS), HbA1c and fructosamine have significantly increased in T2DM patients compared to healthy controls (p<0.0001). FBS, PPBS, HbA1c, and Fructosamine have a significant positive correlation in T2DM patients (p<0.01). Fructosamine has a significant positive correlation with FBS, PPBS and HbA1c (p<0.01, p<0.01, p<0.01, respectively). A linear regression was performed to find the predictor of Fructosamine. The model showed HbA1c as the only strong predictor (p=0.002). In addition, a linear regression was performed to find the predictor of HbA1c. The model showed FBS and Fructosamine as the strong predictors (p=0.000, p=0.002, respectively). Conclusion: Fructosamine has a significant positive correlation with FBS, PPBS, and HbA1c in T2DM patients. HbA1c has been observed as a strong predictor of fructosamine. However, FBS and fructosamine have seen as strong predictors of HbA1c. Fructosamine may act as a potential biomarker for the diagnosis of diabetes and its complications in the Asian population.
Authors and Affiliations
Saba Khan
Keywords
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