Association of Fructosamine and HbA1c in Newly Diagnosed Type 2 Diabetes Mellitus Patients
Journal Title: Indian Journal of Basic and Applied Medical Research - Year 2018, Vol 7, Issue 2
Abstract
Introduction: Uncontrolled blood sugar is the main culprit for high levels of morbidity and mortality in diabetic patients worldwide. The blood glycated hemoglobin (HbA1c) and fructosamine provide a good picture of average plasma glucose for the previous 2-3 months and 2-3 weeks, respectively. Aim: To associate the HbA1c and Fructosamine in newly diagnosed Type 2 diabetes mellitus (T2DM) patients to find an alternative marker and better predictor for the early development of diabetic complications. Material and Methods: Total 70 subjects (35 T2DM and 35 age and gender-matched healthy controls) were enrolled from the rural and suburban population of North India. Biochemical investigations were performed by commercial kits using Chemistry Auto-analyzer. P<0.05 was considered statistically significant. Result: The mean of fasting blood sugar (FBS), post-prandial blood sugar (PPBS), HbA1c and fructosamine have significantly increased in T2DM patients compared to healthy controls (p<0.0001). FBS, PPBS, HbA1c, and Fructosamine have a significant positive correlation in T2DM patients (p<0.01). Fructosamine has a significant positive correlation with FBS, PPBS and HbA1c (p<0.01, p<0.01, p<0.01, respectively). A linear regression was performed to find the predictor of Fructosamine. The model showed HbA1c as the only strong predictor (p=0.002). In addition, a linear regression was performed to find the predictor of HbA1c. The model showed FBS and Fructosamine as the strong predictors (p=0.000, p=0.002, respectively). Conclusion: Fructosamine has a significant positive correlation with FBS, PPBS, and HbA1c in T2DM patients. HbA1c has been observed as a strong predictor of fructosamine. However, FBS and fructosamine have seen as strong predictors of HbA1c. Fructosamine may act as a potential biomarker for the diagnosis of diabetes and its complications in the Asian population.
Authors and Affiliations
Saba Khan
Keywords
Related Articles
- EP ID EP555878
- DOI -
- Views 146
- Downloads 0
Study of incidence of medical neurological causes of hyponatremia
Introduction: Hyponatremia is a common electrolyte disturbance due to various causes. Hyponatremia is of clinical significance as a rapidly decreasing serum sodium concentration as well as rapid correction of hyponatremi...
Unilateral Spinal Anaesthesia for Knee Arthroscopy: A Randomised Controlled Trial of Hyperbaric Solutions of Ropivacaine Alone and Clonidine and Fentanyl as Adjuvants
Objectives: To evaluate the clinical effects of hyperbaric ropivacaine alone and with clonidine or fentanyl for spinal anaesthesia for knee arthroscopy. Methods: Sixty ASA I/II patients were randomised to receive spinal...
Effectiveness Of Oropharyngeal Exercises In Patients with Moderate Obstructive Sleep Apnoea Syndrome
Introduction: Sleep apnea is an entity characterized by repetitive upper airway obstruction resulting in nocturnal hypoxia and sleep fragmentation daytime hypersomnolence Excessive day time sleepiness is a cardinal sympt...
Demodex Folliculoris Dermatitis
This is a case report of Demodex folliculorum of the forehead, scalp, and face of a 64-year-old male farmer from Sudan presenting with pruritic papular and erythematous skin lesions for 6-months. Demodex infestation of t...
Non-functioning Pituitary Macroadenoma: various clinical presentations in general medicine: A case series
Authors describe diagnosis of pituitary adenoma on the background of various clinical presentations in four patients of different ages and sex with proper endocrine and imaging evaluation. Three of them were newly diagno...