Association of higher circulatory levels of homocysteine with additional risk factors in CAD patients
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Coronary artery disease (CAD) is a leading cause of mortality worldwide. In developing countries it has been observed that stressful life style is mainly associated with CAD. Inflammatory environment has been produced due to formation of various oxidant and proinflammatory molecules which keeps inflammatory pathways active. Aim: The present study aimed to compare the circulatory levels of homocysteine in CAD patients and normal controls. Methodology: The study protocol was approved by institutional ethical committee. Total 198 subjects (107 CAD patients and 91 age sex matched controls) have been included in the present study. Blood sugar, lipid profile levels were estimated in both CAD patients and controls. Results: High levels of homocysteine have been observed in CAD subjects [17.41± (10.27)] compared to the controls [7.38± (3.67)]. No significant difference have been observed in LDL levels in controls and CAD respectively [105.32(±33.66)/ 108.93(±41.51)]. However HDL levels were found to be significantly lower in CAD patients than controls [38.71 (±13.73)/ 44.94(±11.34). Additional risk factors like Type 2 diabetes (DM) and Hypertension (HTN) in CAD group has shown high homocysteine than CAD patients without any additional risk factors. Conclusion: Hyperhomocysteinemia is found to be associated with CAD patients. It was also observed that increased pattern of homocysteine levels in CAD patients were associated with additional risk factors like DM and HTN factors.
Authors and Affiliations
Thomas James, Vidhate Deepali Amarsinh, Murarka Arpith, Dhadialia Simranjit Kaur, Shakya Prashant Sing, Chavan Aarati
Keywords
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