Association of Interleukin 10 Gene Polymorphism with Psoriasis in Chinese Population.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 12
Abstract
Background: Psoriasis is a chronic, inflammatory, T cell-mediated cutaneous dermatosis. It is found to be associated with an over expression of T helper1 and Th17 cytokines and relative under expression of Th2 and T-regulatory cytokines. Interleukin-10 is an immunosuppressive cytokine produced mainly by Th2 and T regulatory cells. Genetic polymorphism of the IL-10 gene can lead to the imbalance of Th1/Th17 and Th2/T reg cytokines and results in a decrease in the production of anti-inflammatory cytokines like, IL-10. Relative deficiency of IL-10 and T reg cells play a main role in the pathogenesis of psoriasis. We aimed to find out the association of IL-10 gene (rs1800871 and rs1800896) polymorphism and susceptibility to psoriasis in Han Chinese population. Methods: This study included 44 patients with psoriasis recruited from outpatient and inpatient department of dermatology, Zhongnan Hospital, China. Out of 44 patients, 40 were males and 4 were females. Their age group ranged from 9 to 86 years. Their genotypes were compared with 50 healthy controls of same age group and locality. Psoriasis patients and healthy controls were genotyped for IL-10 gene (rs1800871 and rs1800896) polymorphism by polymerase chain reaction. Results:The genotypic frequencies of IL-10 rs1800871 in psoriasis patients were found to be GA (40.91%), GG (6.82%), AA (52.27%) and in controls GA (34%), GG (20%), and AA (46%). The frequency of minor allele G was found to be 54.55% in cases and 74% in controls. The genotypic frequencies of rs1800896 were found to be CT (11.36%), TT (88.64%), in psoriasis patients and CT (26%), TT (74%), in controls. The frequencies of minor allele C was found to be 11.36% in psoriasis patients and 26% in controls. The p-value, odds ratio (OR) and 95% CI of genotypes of rs1800871 are as follows, GA (p = 0.8990, OR =1.06 & 95% CI = (0.44-2.52), GG (p = 0.0840, OR = 0.30 and 95% CI = (0.08-1.17) and for the minor allele G (p = 0.1550, OR= 0.64 and 95% CI = (0.34-1.18) which are not statistically significant. The p value, OR & 95% CI of genotypes of rs1800896 are CT (p=0.0720, OR=0.36, 95% CI = 0.12-1.09) and for the minor allele C (p=0.0890, OR=0.40, 95% CI=0.14-1.15) which are also not statistically significant. Genetic model analysis also showed no significant association. We observed that IL 10 gene (rs1800871 and rs1800896) polymorphism were not associated with risk of psoriasis. (p >0.05). Conclusion:Our results suggest that IL-10 gene (rs1800871 and rs1800896) polymorphism have no association with risk of psoriasis in the Han Chinese population. The Chinese population is not susceptible to psoriasis associated with IL-10 gene polymorphism.
Authors and Affiliations
Song Jiquan
Keywords
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