Association of Interleukin-1β +3954 (Rs1143634) Gene Polymorphism in Periodontal Healthy and Chronic Periodontitis Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 8
Abstract
Background: Polymorphisms of various cytokine genes are known to influence the pathogenesis and severity of several inflammatory conditions. The association of these polymorphisms with chronic periodontitis(CP) susceptibility has been found to be diverse amongst different ethnic populations. This study was aimed to determine the distribution of IL-1β+3954 (rs1143634)gene polymorphismin healthy controls(HC) andCP and to explore their association with periodontal status. Methodology:The above polymorphism was analysed amongst HC(n=56) and CP patients (n=79). Genotyping was performed using PCR-RFLPassay. Mann-Whitney U test and Kruskal Wallis ANOVA test were applied to find out the differences in genotypes of SNPs with clinical parameters and chronic periodontitis. Results:No significant correlation was found between IL-1β+3954 (rs1143634)gene polymorphism and both groups though the frequencies of C/C genotype and allele T were higher in CP. Conclusion:Lack of association ofIL-1β+3954 (rs1143634)gene polymorphismwasobserved with chronic periodontitis in the population of Northern Karnataka.
Authors and Affiliations
Dr Swati Setty, DrPragathiR. Bhat, Dr Bhushan Kulkarni, DrShivprakashV Hiremath, Dr Srinath Thakur
Keywords
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