ASSOCIATION OF MATERNAL OBESITY, BIRTH-WEIGHT, INSULIN LEVELS AND HOMA-IR IN NEWBORNS AT TERM IN A TERTIARY CARE CENTRE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 15
Abstract
BACKGROUND Intrauterine environment represents a time when changes in metabolism may affect distant metabolic dysfunction in the offspring mediated through physiological and epigenetic mechanism. Maternal pregravid weight\BMI is associated with increased birth weight and insulin resistance in neonates. Maternal obesity and underlying insulin resistance are significant short and long-term risk factors for both the mother and her fetus which create the potential of a vicious cycle of obesity & insulin resistance and development of diabetes in later life. We wanted to evaluate the association of maternal pregravid obesity with birth-weight and HOMA-IR in newborns at term. METHODS This is a cohort study for a period of one year from Dec. 2010 to Nov. 2011. Neonates of forty lean (BMI < 25 kg/m2) and forty obese women (BMI > 30 kg/m2) with singleton term pregnancy were evaluated at elective cesarean section over a period of one year. RESULTS There was a positive relationship between maternal pregravid BMI, birth-weight and newborns insulin resistance (r = 0.438, p = 0.0001). CONCLUSIONS In the present study, Insulin resistance indices (HOMA-IR) were higher in obese mothers (mean value 4.25 ± 1.11) as compared to that of lean mothers (mean value 1.85 ± 0.64). The HOMA-IR index was also higher in newborns of obese mothers (1.61 ± 0.45) as compared to newborns of lean mothers (mean value 1.12 ± 0.42) and this difference was observed to be statistically highly significant (p = 0.0001). There was a positive relationship between maternal pregravid BMI, birth-weight and newborns insulin resistance (r = 0.438, p = 0.0001).
Authors and Affiliations
Vinod Kumar, Shahbaz Khan, Joginder Singh
Keywords
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- EP ID EP557369
- DOI 10.14260/jemds/2019/271
- Views 76
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