Association of Matrix Metalloproteinase-2 Gene Promoter Polymorphism and the Associated Phenotype Variation with Myocardial Infarction
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 7
Abstract
MatrixMetalloProteinases-2, are zinc dependent endopeptidases which degrade major components of the basal lamina around blood vessels. Myocardial Infarction is mainly due to atherosclerosis of the coronary arteries. MMP-2 destabilizes the arterial wall and breaks atheromatous plaque leading to MI. The gene for human MMP-2 contains 27,862 base pair genomic DNA and is composed of 13 exons. Several common restriction fragment length polymorphisms (RFLPs) have been reported in the MMP-2 gene locus.100 diagnosed myocardial infarction patients were taken as cases.100 Age, sex matched individuals taken as controls. Autoimmune, thyroid, neoplastic, hepatic and chronic infections were excluded. Plasma MMP-2 levels were determined by ELISA and Genotyping was done by PCR-RFLP. Plasma MMP-2 level was increased in patients with myocardial infarction. Genotype frequency distribution between cases and controls were compared with a 2 test. MMP-2 activity was compared between controls and cases by Student t test, p value < 0.05 was considered significant. Keywords:Matrixmetalloproteinases, Myocardial Infarction, MMP-2gene, Restriction fragment length Polymorphism, Atheromatous plaque
Authors and Affiliations
Dr. B. Sudhapresanna, Dr. Pragna B. Dolia, Dr. C. Shanmuga Priya
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