Neurodynamics of Temporal Lobe Epilepsy in Fronto-Central region of Cerebral Cortex

Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 7

Abstract

Abstract:Temporal lobe Epileptic (TLE) seizures are preceded by changes in signal properties detectable by scalp EEG but our ability to understand brain dynamics associated with epilepsy remains limited. EEG-based epilepsy diagnosis and seizure detection is still in its early experimental stages. The problem is further amplified for the design and development of automated algorithms, which requires a quantitative parametric representation of the qualitative or visual aspect of the markers. The study was performed in Department of Physiology, SMS Medical College in collaboration with Department of Neurology and Medicine. Using EEG data from 16 controls and 16 temporal lobe epilepsy (TLE) patients, in this study we characterize how the dynamics of the healthy brain differ from the dynamically balanced state of the brain of epilepsy patients treated with anti-epileptic drugs in the context of resting state during eye close session. Such differences can be observed by using absolute spectral band power from BESS ((Brain Electro Scan Software) of the Axxonet System and network measures by applied unpaired student t -test. During eye close, fronto- central theta (p 0.0004), beta (p 0.00005) and gamma (p 0.0179), bands absolute spectral power found significant difference in temporal lobe epileptic patients during interictal period of epilepsy when compared with healthy controls. In conclusion we found that low frequency band mainly theta and high frequency band beta were more pronounced in fronto central region of brain in temporal lobe epileptic patients. Though frontal region is requisit to short-term memory so the patients of TLE may be suffer from memory dysfunction in future. Various linear and nonlinear analytical methods would be helpful in extracting information from EEG signalsin diagnosing specific neuronal correlates for TLE. Keywords:Absolute spectral power analysis,Dynamics of brain, EEG analysis, Neurodynamics, Temporal lobe epilepsy.

Authors and Affiliations

Shikha Saxena, Kapil Gupta, Jitendra Gupta, Anjani Sharma

Keywords

Related Articles

Chloroquine Vs Co-Artemether in Uncomplicated Malaria

Abstract: The objective of this paper was to compare the efficacy of chloroquine and co-artemether in uncomplicated malaria cases. It was a prospective interventional study. The subjects included children with PBF proven...

Phototherapy Induced Hypocalcemia in Neonates

The objective is to study the effect of phototherapy on serum calcium in neonates. A Cross sectional study was performed in a Tertiary care centre, Gandhi Medical College, Bhopal. Study group includes neonates with hyper...

Matrix Metalloproteinases (MMPs) in Oral Squamous Cell Carcinoma

Abstract:Tumor growth and development involves interaction between tumor cells and extracellular matrix components characterized by cell proliferation, survival, migration into other tissues by invasion or metastasis. Mi...

Presentations and Management of Colorectal Cancer in under 40 Years of Age in the Sub-Saharan Africa: A Multi-Centre Study

Colorectal cancer in young adults is commoner in Black Africans and is one of the leading causes of cancer - related death in this race. The aim of the study was to identify the presentation pattern and management of col...

Anti-ulcer activity of Nardostachys jatamansiagainst pylorousligation induced gastric ulcer

Abstract: The present study was designed to evaluate the effects of hydroalcoholic extract of Nardostachys jatamansi on experimentally induced ulcer by pylorousLigation method. The extract (500 mg/kg) was administered or...

Download PDF file
  • EP ID EP375041
  • DOI -
  • Views 78
  • Downloads 0

How To Cite

Shikha Saxena, Kapil Gupta, Jitendra Gupta, Anjani Sharma (2017). Neurodynamics of Temporal Lobe Epilepsy in Fronto-Central region of Cerebral Cortex. Scholars Journal of Applied Medical Sciences, 5(7), 2823-2829. https://europub.co.uk/articles/-A-375041