Association of mean platelet volume and platelet distribution width with diabetic retinopathy in patients with diabetes mellitus
Journal Title: Indian Journal of Clinical and Experimental Ophthalmology - Year 2018, Vol 4, Issue 4
Abstract
Introduction MPV and PDW are indicators of subclinical platelet hyperactivity and can be used as predictive factors for development and progression of diabetic retinopathyMaterials and Methods This prospective case control study enrolled 150 patients with diabetic retinopathy DR group and 150 diabetic patients without retinopathy control group Detailed history and ophthalmic examination was done The DR group was divided into 5 subgroups according to the ETDRS classification of diabetic retinopathy MPV PDW FBS and PPBS values were obtainedResult The mean value of MPV in DR group was higher compared to control group p0016 PDW also followed the similar trend with DR group having mean value of 1371 136 fl and control group having 1213 129 fl p0023 The study also found a trend of increase in severity of diabetic retinopathy with increasing level of MPV and PDW However a statistically significant association was found only between MPV and stage of diabetic retinopathy r 0214 p 0046 A marked increase in MPV and PDW values were found in those with Proliferative diabetic retinopathy pConclusion Platelet indices like MPV can be a cheap and easy to measure tool for monitoring diabetic retinopathyKeywords Mean platelet volume Platelet distribution width Diabetic retinopathy Proliferative diabetic retinopathy
Authors and Affiliations
Shubhratha S. Hegde, Mahima S. R, Sandhya Dharwadkar, Mohammad Abdul Kayoom N, Shashidhar H. B
Keywords
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- EP ID EP474870
- DOI 10.18231/2395-1451.2018.0119
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