Association of Parathyroid Hormone with Markers of Bone-Mineral Metabolism in Patients of Chronic Kidney Disease with Secondary Hyperparathyroidism
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 6
Abstract
Background: Secondary hyperparathyroidism (SHPT) is one of the most obvious complications of chronic kidney disease (CKD). The pathogenesis of SHPT is complex and dependent on the imbalance of various biochemical markers of bone and mineral metabolism. Aim: The present study was planned to evaluate the association of intact Parathyroid Hormone (iPTH) levels in CKD patients with bone-mineral metabolism markers. Materials & Methods: Fifty diagnosed cases of CKD (stage 4 & 5), age up to 60 years were enrolled for the study. Fifty age and sex matched healthy individuals constituted the control group. Blood samples were collected using standard aseptic technique and subjected to analysis for serum Urea, Creatinine, uric acid, Calcium, Phosphorus, Alkaline phosphatase, 25(OH) Vitamin D and intact parathyroid hormone. Estimated Glomorular Filtration Rate was calculated by applying Cockeroft and Gault formula. Results obtained were compared between CKD patients and control group statistically by applying students’ t-test. Pearson correlation for iPTH and other parameters were also evaluated. Results: Besides deranged renal function, CKD patients exhibited hypovitaminosis D and hyperparathyroidism. The study also reported low levels of S Ca++, while S phosphorus and ALKP were significantly higher. iPTH demonstrated a significant negative correlation with S Ca++ (r = -0.418). A significant correlation was also observed between iPTH and S phosphorus(r =0.554) and ALKP (r=0.291). Conclusion: Hyperparathyroidism is a common complication of end stage renal disease (ESRD). iPTH demonstrates strong association with S. Ca++, Phosphorus and ALKP, which are directly responsible for homeostasis of bone-mineral metabolism, in CKD patients. Monitoring of these markers in CKD patients shall be helpful in better management and in diminishing the occurrence of various comorbid conditions
Authors and Affiliations
Bushra Fiza, Jai Prakash, Suraj Godara, Maheep Sinha
Keywords
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- EP ID EP548391
- DOI 10.21276/ijmrp.2017.3.6.009
- Views 85
- Downloads 0
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