Clinical Profile of Acute Organophosphorous Poisoning with Special Reference to Serum Creatine Phosphokinase and Serum Lactate Dehydrogenase Levels as Prognostic Markers: A Tertiary Care Hospital Based Observational Study in North-East India
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 6
Abstract
Introduction: Organophosphorous compounds poisoning are a common cause of high morbidity and mortality in India owing to their low cost and easy availability. This study was undertaken to assess severity of organophosphorous compound poisoning clinically by using Peradeniya scoring & to assess correlation between serum Creatine Phosphokinase and Lactate Dehydrogenase levels with severity of acute OP poisoning. Methods: We conducted a hospital based observational study comprising of 93 patients of Acute Organophosphorus Poisoning on basis of history of ingestion of organophosphorus compounds as said by the patient or attendant and with relevant clinical findings who had attended Medicine O.P.D/Casualty and was admitted in Gauhati Medical College and Hospital, Assam, India and fulfilled the inclusion and exclusion criteria. Statistical analysis was performed using GraphPad InStat version 3.00 for Windows 7, GraphPad Software, San Diego California USA. Results: In our study, 51.61% were males and 48.39% were females. 35.48% was in second decade of life followed by third decade (30.12%). As assessed by POP Scale, 7.54% presented with most clinical severity (>8). 7.53% of total patients expired. 5.38% of expired patients had S. CPK level more than 1000U/L (p-value 0.0001). Of total patients expired, 6 (6.45%) patients had S. LDH levels less than 1000U/L and 1 (1.08%) patient had S.LDH level more than 1000U/L (p- value 0.259). Conclusion: Early clinical assessment and grading according to Peradeniya Organophosphorous poisoning score correlated in predicting mortality. An association between Creatine Phosphokinase levels and higher rate of mortality was observed and this area needs to be particularly focussed.
Authors and Affiliations
Mrinali Rabha, Chitralekha Baruah, Monmohan Boro
Keywords
Related Articles
- EP ID EP548717
- DOI 10.21276/ijmrp.2017.3.6.018
- Views 71
- Downloads 0
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