Association of polymorphism of Enzyme Thiopurine Methyl Transferase in Head & Neck Squamous Cell Cancer and treatment response to Concurrent Chemo Radiotherapy
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Objectives: The aim of the present study was to determine the frequency of the functional TPMT polymorphisms and their association with the treatment outcome in patients of HNSCC receiving cisplatin based chemoradiation. Methods: 100 patients of locally advanced head & neck squamous cell carcinoma and 100 controls frequently matched with cases were enrolled in the study. Allelic variant of TPMT gene was done with the help of RFLP PCR analysis. All patients received radiation 70 Gy with concurrent cisplatin 35 mg/m2 every weekly. Response assessment was done with help of World Health Organization (W.H.O.). Results: Majority of Indian population had TPMT*3B wild genotype. The patients carrying the wild type genotype of all four alleles responded to Chemoradiation, while TPMT*3B heterotypes and TPMT *3C homozygous mutant form were found among the non responder patients. Conclusion: Genotyping of TPMT helps us to identify responders and non responders to standard treatment and enhances the precision regarding selection of treatment modality.
Authors and Affiliations
Sandip Barik
Keywords
Related Articles
- EP ID EP285050
- DOI -
- Views 58
- Downloads 0
Obstructive Sleep Apnea and Oral Appliances- Review
Obstructive sleep apnea is a chronic, progressive and disabling sleep related breathing disorder. It requires long term, multidisciplinary management .Various treatment modalities such as behavioural, medical, surgical o...
An Unusual presentation of Gastric Gastro intestinal Stromal Tumour: A Case Report
Gastro-intestinal stromal tumours (GIST) are uncommon malignancies of the gastro-intestinal tract and can occur in any part of the alimentary canal , from esophagus to anus. The most common sites of presentation are stom...
Knowledge about swine flu (H1N1) among pregnant women attending antenatal care clinic in a tertiary care hospital in central India
Background: In India the first positive case of pandemic H1N1 was reported in May 2009 and by end of the year 2010, 20604 cases with 1763 deaths were reported. Since 2010 Maharashtra has been reporting cases of Swine flu...
To study the association of high risk factors and the postpartum hemorrhage at Tertiary Care Centre of Indore
Postpartum haemorrhage (PPH) is a potentially life-threatening event. In the majority of cases, relatively simple methods are used to avert a disaster, although these are not always employed.[1] Uterine tamponade using i...
Study on Demographic & Clinical Profile of Children with Bronchiolitis AGED 2 – 24 Months
Background: Bronchiolitis is one of the most common lower respiratory tract infection in the children aged two months to twenty four months.The illness is often caused by viral infection with varying clinical presentatio...