Association of porcine STIM1 gene with litter size traits
Journal Title: Animal Science Papers and Reports - Year 2016, Vol 34, Issue 2
Abstract
In commercial pig production, litter size has always been one of the most important production traits. Stromal interaction molecule 1 (STIM1) is a transmembrane-spanning Ca2+-binding protein, which is essential for oocyte maturation and fertilization, as well as proper embryo development. The objectives of this study were to identify mutations in the porcine STIM1 gene and investigate the association between genetic variations and litter size traits in pigs. A novel 1bp - deletion/insertion in intron 10 (g.199893-delT) and a single nucleotide polymorphism (SNP) in exon 10 (g.1969037T>C) were found by sequencing. Association results showed that these two mutations significantly affected litter size traits in both the DIV line and Large White pigs (P<0.05). In all parities sows with the TT genotype of g.1969037T>C had significantly more piglets than those of the CC genotype (P<0.01), and the number of piglets decreased in the following order of genotypes TT>CT>CC. The sows with the NN genotype of g.199893-delT had significantly more piglets than those of the MM genotype (P<0.01), and the number of piglets decreased in the following order of genotypes NN>MN>MM. Here we provide evidence that the mutations in the porcine STIM1 gene affected litter size of sows, and that this gene might be a potential important candidate gene related to litter size in pigs.
Authors and Affiliations
J. J. Wu, X. W. Peng, F. E. Li, M. Qiao, H. Y. Wu, S. Q. Mei
Keywords
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