Association of Serum Magnesium Level with Major Risk Factor, Thrombolysis and Echocardiography in Patients with Acute Coronary Syndrome
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 3
Abstract
Megnesium depletion plays a key role in the pathphysiologic features of diabetes mellitus, hypertension, thrombosis, arrhythmias and coronary artery disease. Whether the depletion is related to the Echocardiographic parameters in an acute phase of acute coronary syndrome is not known. The objective of the study is to explore the status of serum magnesium in acute coronary syndrome patients. To investigated the association of serum magnesium levels with major risk factor, fibrinolysis and echocardiography in Patients with acute coronary syndrome. The 68 patients with were divided into three groups: STEMI, NSTEMI and unstable angina. The 24 healthy individuals matched as a control group. Serum Mg was measured in all patients groups and control group, the analysis is performed in an atomic absorption spectrophotometer (Schmiadzu AA5646). Estimation of serum glucose, urea, creatinine, lipid profile was done by colorimetric method. The mean ±SD value of serum Mg levels in patients with ACS was significantly lower than those in normal controls. ANOVA test revealed there was non significant difference in the value of serum Mg mean ±SD levels among three types of acute coronary syndrome, t- test revealed there was non significant difference in the value of serum Mg mean±SD levels in the presence or absente of diabetes millitus, Dyslipidemia, Hypertension, Smoking, Obesity and fibrinolytic treatment. The mean (±SD) value of serum Mg levels was non-significantly associated with mitral regurgitataion (MR) severity and diastolic dysfunction stages. There was non-significant correlation between the serum Mg concentration and the value of Isovolumic relaxation time, E (left ventricular inflow velocity) / e (tissue doppler velocity) ratio and Decceleration time, Age, Diameter of left atrium and Left Ventricular Ejection Fraction (LVEF). Decreases Serum magnesium level indicate ischemia severity in acute coronary syndrome patients, Serum magnesium level non significantly associated with major risk factor, fibrinolytic treatment and Echocardiographic parameter in acute phase of disease.
Authors and Affiliations
Dr. Wafa Mansor Merza
Keywords
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