Association of Serum Soluble Endoglin Levels with Adverse Foetomaternal Outcome in Preeclampsia and Eclampsia
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 4
Abstract
Background: Serum Endoglin has also previously shown to be elevated in woman with established preeclampsia especially in those presenting with preterm labour and foetal growth retardation. Objectives: To evaluate association of serum soluble Endoglin with adverse foeto-maternal outcome in woman with hypertensive disorders of pregnancy. Materials and Methods: A prospective case control study carried out from 2013 to 2014 at department of Obstetrics and Gynaecology. Ethical clearance was obtained from institutional ethics committee No.ECR/262/Inst/UP/2013 from King Georges Medical University, Lucknow. After informed consent, total 90 pregnant women from gestational age 20-40 weeks were enrolled after randomization. 30 women of preeclampsia and 30 of antepartum eclampsia served as cases where as 30 normotensive pregnant women served as controls. Preeclampsia was defined as per NHBPEP2000 working group. Estimation of serum soluble Endoglin level was done by Enzyme linked immunosorbent assay using ELISA kit. Results: Serum Endoglin levels were found higher in preeclampsia and eclampsia group (p<0.001) in comparison to controls. The women who had complication in terms of postpartum haemorrhage, cerebrovascular accident during the study had maternal serum Endoglin levels 12.48 ng/ml, and 16.08 ng/ml, respectively in preeclampsia group and 15.88 ng/ml, 16.76 ng/ml respectively in eclampsia group. 4 women expired, all were from eclampsia group mean serum Endoglin level of these women was 14.18±2.4. Serum Endoglin levels increased with low birth weight in preeclampsia and eclampsia. 12 neonates in preeclampsia and 17 neonates in eclampsia, required admission to NICU, in whom the maternal serum Endoglin level was 14.67±1.77, 15.68±1.48 respectively, which was higher than those neonates who did not required admission & difference was statistically significant (p<0.001). Neonates who died had high maternal S. Endoglin level (15.77±0.44 and 16.23±1.30) as compared to alive foetuses (12.35±2.49, 14.30±1.86 respectively). Conclusion: Serum soluble Endoglin level might predict adverse foetomaternal outcome, but larger studies should be carried out to confirm this association.
Authors and Affiliations
Rekha Sachan, Munna Lal Patel, Pratima Verma, Soniya Dheeman, Pooja Gupta
Keywords
Related Articles
- EP ID EP341059
- DOI 10.9734/BJMMR/2016/28862
- Views 83
- Downloads 0
Resting Salivary Flow Rate and pH Decreases in Chewable Tobacco Users
Background: Salivary flow rate and pH may be altered by chewable tobacco, the habit which is becoming a threat for oral cancer epidemic. The objective of the study was to find out the relationship between alterations in...
An Update on Cephalometrics among Nigerians: Ascertaining Prevalent Jaw Patterns
Aims: Cephalometric norms vary between populations as well as among ethnicities within a known population. This study presents an update on cephalometric findings among Nigerians as well as the prevalent jaw patterns amo...
Mortality Rate Pre-assessment Based on Trips Score
Treatment and care for newborn babies are provided at medical centres by personnel with the required education and experience using special equipment. Similar to the situation in many other countries, centres with such c...
Comparison of the Automatic Non-invasive Express Screening Analyser (ANESA)® for Clinical Analytical Parameters
Background: The objective we evaluated the reliability of some haematological and biochemical parameters performed by a non-invasive auto-analyser (ANESA) with those obtained by the standard method of venipuncture (refer...
Hepatocellular Carcinoma Sub-types in North-Central Nigeria: A Histological Review of Liver Biopsies
Introduction: Hepatocellular carcinoma (HCC) is the 6th most common cancer worldwide and a greater burden of this disease is born by the hepatitis B virus (HBV) endemic and resource deficient sub-Sahara Africa. This inve...