Association of Tissue Transglutaminase with Nerve Growth Factor, Prolidase Activity and Oxidative Stress in Celiac Patients
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 11
Abstract
ABSTRACT Introduction: Celiac Disease (CD) is an autoimmune gastrointestinal disorder; it is characterised by chronic inflammation and elevation of tissue Transglutaminase Immunoglobulin-A (tTG-IgA). Nerve Growth Factor (NGF) and prolidase enzyme are elevated in different autoimmune and chronic inflammatory diseases; however, the status of NGF and prolidase enzyme remains unexplored in celiac patients till date. Aim: To evaluate the correlation of tTG-IgA to NGF, Serum Prolidase Activity (SPA) and oxidative stress in the CD patients. Materials and Methods: The study was conducted on a total of 92 subjects, 46 patients with CD and remaining 46 healthy controls. The tTG-IgA and NGF were measured with the use of ELISA kit. SPA and oxidative stress were measured spectrophotometrically. Results: The tTG-IgA, NGF, SPA, Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) were significantly elevated in the serum of patients as compared to controls (all p<0.001); however, Total Antioxidant Status (TAS) was significantly decreased (p<0.001). The tTG-IgA showed a positive correlation with NGF, SPA, TOS and OSI in the patients (all p<0.001); while it was negatively correlated to TAS (p<0.001). Conclusion: The present study concluded that elevated NGF, prolidase enzyme, tTG and oxidative stress might be associated with the pathogenesis of celiac disease.
Authors and Affiliations
Akhilesh Kumar Verma, Ankur Sharma, BK Das, Shalabh Srivastava, Ragini Srivastava
Keywords
Related Articles
- EP ID EP524327
- DOI 10.7860/JCDR/2018/37282.12197
- Views 67
- Downloads 0
Crossed Fused Renal Ectopia showing Pelviureteric Junction Obstruction with Single Ureter and Single Renal Artery
ABSTRACT Crossed fused renal ectopia is a rare anomaly remaining asymptomatic by far and detected invariably as either incidental finding or in view of pre-existing kidney disease. We report a case of crossed fused renal...
Narratives as Active Learning Strategy to Emphasise the Clinical Relevance of Enzymology in Medicine
ABSTRACT Introduction: Student learning is dictated by the learning environment rather than the inherent qualities of the learner. Mode of curriculum delivery heavily influences the learning environment and pushes the le...
Single Nucleotide Polymorphism of Thyroid Hormone Receptor α Gene can be a Risk of Atherogenic Dyslipidemia
ABSTRACT Introduction: Dyslipidemia and atherosclerosis are common occurrence in hypothyroidism. Not all patients suffering from hypothyroidism present alteration of lipid profile pertinent to atherogenesis characterised...
Radiotherapy in Phyllodes Tumour
Introduction: Phyllodes Tumour (PT) of the breast is a relatively rare breast neoplasm (<1%) with diverse range of pathology and biological behaviour. Aim: To describe the clinical course of PT and to define the role of...
Bone Mineral Density among Lean Type II Diabetes Mellitus Patients-A Cross-sectional Comparative Study
ABSTRACT Introduction: In case of diabetes mellitus, the pathological process behind fragility of the bone are complex. This process is found to be mediated by various factors like hyperglycaemia, oxidative stress and th...