Association of turner syndrome with hypothyroidism
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 2
Abstract
To create awareness about association of turner syndrome with hypothyroidism. TS affects 1/2,500 female births and is due to the absence/structurally abnormal sex chromosome and characterized by short stature and oestrogen deficiency, secondary to ovarian dysgenesis. Approximately 1/3 has a thyroid disorder, usually hypothyroidism. In most cases, it is caused by an immune system attack (Hashimoto's thyroiditis). To create awareness about association of turner syndrome with hypothyroidism. A 14 years old female presented with short stature, primary amenorrhea, non-development of breast, webbed neck, no pubic hair with sexual infantilism with disinterest in school. Due to this phenotype, turner syndrome was suspected. There was fatigue, exhaustion, feeling cold, constipation, muscle cramps, dry, coarse, itchy skin, thinning hair. Diagnosis is confirmed by the presence of a 45 X cell line. Thyroiditis with hypothyroidism is confirmed by presence of elevated TSH 17.22 uIU/ml (0.35-5.50), normal T3 & T4 and elevated anti-TPO. Atria et al1 1948 reported the post-mortem findings of a small thyroid gland with lymphocytic infiltration in a young TS woman. The association has since been confirmed in TS with a high incidence of Hashimoto’s disease and elevated thyroid antibodies2-8. S Livadas et al9 analysed 84 girls with TS and Hypothyroidism was detected in 24% and hyperthyroidism in 2.5%. There is association of turner syndrome with thyroid disorder, usually hypothyroidism.
Authors and Affiliations
Sandeep Aggarwal, Shallu Aggarwal
Keywords
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