Association of Vitamin C with Erythrocyte Malondialdehyde Levels in Type 2 Diabetic Patients - A ClinicalApproach
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 11
Abstract
Abstract: Oxidative stress plays a crucial role in the pathogenesis of various health related complications including type 2 diabetes mellitus (T2DM). Although role of free radicals mediated lipid peroxidation in T2DM are well documented, its association with vitamin C levels in T2DM pathophysiology along with cardio vascular disease (CVD) risk has yet not been focused. The present study was carried out to estimate the plasma vitamin C levels, an aqueous medium containing non-enzymic antioxidant and malondialdehyde (marker of lipid peroxidation) in T2DM subjects. Material In the present study, plasma vitamin C levels and malondialdehyde levels were measured in 100 type 2 diabetic subjects of either sex (35-55 years) and statistically compared it with that of 100 healthy individual, served as control. Plasma vitamin C levels were found to be significantly low in patient group as compared to control (P < 0.001) whereas erythrocyte malondialdehyde levels and fasting blood glucose levels were increased significantly in patient group as compared to control (P < 0.001). In addition, plasma vitamin C level was negatively associated (r = -0.685; P< 0.001) with erythrocyte malondialdehyde levels. These findings suggest that enhanced oxidative stress occurs in T2DM patients as characterized by increased incidence of lipid peroxidation and reduction of vitamin C levels in order to combat free radicals. Therefore, regular consumption of diet rich in vitamin C and antioxidant minerals should be encouraged along with monitoring of glycemic profile, oxidative stress and cardiac markers to move one step ahead in adopting the preventive and regulatory measures against CVD in T2DM patients. Keywords:Lipid peroxidation, ascorbate, hyperglycemia, oxidative stress, free radical.
Authors and Affiliations
Nitin Faldessai, MdMasood Ahmed Shareef, Rahul Saxena, Ijen Bhattacharya
Keywords
Related Articles
- EP ID EP372465
- DOI -
- Views 30
- Downloads 0
Endopthalmitis- Microbiological Profile at a Tertiary Eye Care Hospital in Hyderabad
Abstract: This is a retrospective study aimed to identify the microbial etiology of infectious endophthalmitis cases and to determine the antibacterial susceptibilities of bacterial isolates at Sarojini Devi Eye hospital...
Evaluating the Effect of Intravenous Clonidine and Dexmedetomidine on Haemodynamic Stress Response during Pneumoperitoneum in Laparoscopic Abdominal Surgeries
Laparoscopic surgeries are superior over open surgical procedures and former has now become the gold standard for cholecystectomy. Though laparoscopic procedures are more beneficial and have less complications rate but t...
Potential Protective Role of Cinammon Aquaous Extract against Hypercholesterolemia Induced Testicular Damage in Rats
The present study was aimed to investigate the possible protective effect of cinnamon on the testis against high cholesterol diet of adult Wistar rats through biochemical and histopathological examination. Forty rats we...
Efficacy of Chloroquine against Escherichia Coli and Proteus vulgaris: An in vitro Study
Chloroquine, a 4-aminoquinoline is an effective antimalarial drug and is also used as a systemic amoebicide in the treatment of hepatic amoebiasis (extra intestinal site). The objective of this study is to establish the...
Study of Relationship between Arterial Stiffness and Hypertension in Jodhpur City
Cardiovascular diseases are emerging as one of the leading causes of morbidity and mortality in the Indian population. The major risk factors contributing to cardiovascular diseases include hypertension, diabetes mellitu...