Association of Vitamin C with Erythrocyte Malondialdehyde Levels in Type 2 Diabetic Patients - A ClinicalApproach
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 11
Abstract
Abstract: Oxidative stress plays a crucial role in the pathogenesis of various health related complications including type 2 diabetes mellitus (T2DM). Although role of free radicals mediated lipid peroxidation in T2DM are well documented, its association with vitamin C levels in T2DM pathophysiology along with cardio vascular disease (CVD) risk has yet not been focused. The present study was carried out to estimate the plasma vitamin C levels, an aqueous medium containing non-enzymic antioxidant and malondialdehyde (marker of lipid peroxidation) in T2DM subjects. Material In the present study, plasma vitamin C levels and malondialdehyde levels were measured in 100 type 2 diabetic subjects of either sex (35-55 years) and statistically compared it with that of 100 healthy individual, served as control. Plasma vitamin C levels were found to be significantly low in patient group as compared to control (P < 0.001) whereas erythrocyte malondialdehyde levels and fasting blood glucose levels were increased significantly in patient group as compared to control (P < 0.001). In addition, plasma vitamin C level was negatively associated (r = -0.685; P< 0.001) with erythrocyte malondialdehyde levels. These findings suggest that enhanced oxidative stress occurs in T2DM patients as characterized by increased incidence of lipid peroxidation and reduction of vitamin C levels in order to combat free radicals. Therefore, regular consumption of diet rich in vitamin C and antioxidant minerals should be encouraged along with monitoring of glycemic profile, oxidative stress and cardiac markers to move one step ahead in adopting the preventive and regulatory measures against CVD in T2DM patients. Keywords:Lipid peroxidation, ascorbate, hyperglycemia, oxidative stress, free radical.
Authors and Affiliations
Nitin Faldessai, MdMasood Ahmed Shareef, Rahul Saxena, Ijen Bhattacharya
Keywords
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