Asymetric Dimethylarginine Levels and Dimethylarginine Dimethylaminohidrolase 2 Expression on Nitric Oxide Synthesis Pathway in Sprague Dawley Rats Induced Nicotinamide and Streptozotocin by Giving Physalis angulata L
Journal Title: Scholars Academic Journal of Biosciences - Year 2014, Vol 2, Issue 9
Abstract
Hyperglycemia in patients with diabetes will increase oxidative stress to the endothelium and cause endothelial dysfunction. Endothelial dysfunction related to oxidative stress due to hyperglycemia can be improved through several mechanisms, including the synthesis of nitric oxide pathway (NO). Physalis angulata L is one kind of plant that has been used as an antidiabetic, due to fisalin. The Objective of this study is to determine the levels of Asymetric Dhymetilarginine (ADMA) and expression Dhymethilamine Dehidrolase 2 (DDAH2) on Nitric Oxide (NO) synthesis pathway in Sprague Dawley rats induced Nicotinamide (NIC) - Streptozotocin (STZ) by giving P. angulata L standardized fisalin. The study was true experimental research design with a post-test only control group design. Subjects were 30 male Sprague-Dawley rats induced STZ (45 mg/BW) and NIC (110 mg/BW). Giving P. angulata L standardized fisalin with a dose of 20 mg/BW was conducted for 21 days. Insulin injections of 200 mg/BW and verapamil injections of 1 mg/BW. It is found that there was a significant result (p = 0.009; r = 0.596 and R2 = 0.355) and the effect of variation of 35.5% of the group ADMA levels. There was a significant result (p = 0.004; r = 0.505 and R2 = 0.255) and the effect of variation was 25.5% of the group DDAH2 expression in circular position and there was no effect (p = 0.284; R = 0.202 and R2 = 0.041) on the expression of group variation DDAH2 longitudinal position. In conclusion, giving of P. angulata L standardized fisalin can improve NO synthesis through a decrease in ADMA levels and increased expression of DDAH2.
Authors and Affiliations
Yeny Sulistyowati, Sri Kadarsih Soedjono, Mustofa ,, Budi Mulyono
Keywords
Related Articles
- EP ID EP377999
- DOI -
- Views 44
- Downloads 0
Is Bone Grafting necessary following open reduction and internal fixation of supracondylar/intercondylar femur fracture with locking compression plate?
The common problems seen in distal femoral fractures are communition, articular surface involvement, fractures in multiple planes and bone loss in compound fractures. They present a challenge to the surgeon to achieve st...
Analysis of Rainfall and Temperature Effects on Maize and Rice Productionin Akim Achiase, Ghana
The paper sought to analyse the effects of rainfall and temperature variability on the production of grain crops in Akim Achiase. Data from the Ghana Meteorological Agency (GMA) and the Ministry of Food and Agriculture (...
A study of larval indices of Aedes and the risk for Dengue outbreak
Arboviral diseases are on an increase the world over, especially in developing countries like India. The problem has been perceived to be serious enough for the World Health Organisation to dedicate the World Health Day...
Influences of Exogenous Pro- and Anti-oxidants on Aluminum-induced Behavioral Alterations in Elevated Plus Maze and Passive Avoidance Activity of Rats
Abstract: Exposure to aluminum is always associated with oxidative stress, while, oxidant imbalance is a common observation for degenerative neuropathologies. Recently, oxidative stress and cognitive impairment were asso...
Study on Growth and Reproductive Behavior in Freshwater Catfish (Heteropneustes fossilis)
Abstract: The changes in the gonadosomatic index (GSI) of a catfish, Heteropneustes fossilis was studied for relation between seasonal variation in growth and reproductive cycle . The fish has only one spawning season o...