Asymmetric Dimethylarginine Level as an Indicator for Cardiovascular Risk in Patients with Metabolic Syndrome
Journal Title: European Archives of Medical Research - Year 2020, Vol 36, Issue 3
Abstract
Objective: This study aimed to make an early diagnosis of endothelial dysfunction, the initial pathology of atherosclerosis in metabolic syndrome (MS) patients, and to investigate the usefulness of serum asymmetric dimethylarginine (ADMA) levels as a marker of cardiovascular risk. Methods: Thirty-eight patients (24 women and 14 men) who were diagnosed with MS, according to the National Cholesterol Education Program Adult Treatment Panel III, were included in the study. Patients with a history of systemic diseases, except components of MS, and smokers were excluded from the study. The control group comprised 25 and 12 healthy women and men, respectively; with similar age profiles. Serum ADMA levels and carotid intima-media thickness (CIMT) were measured in patients and controls. Results: Lower serum ADMA levels and higher CIMT measurements were observed in the patient group than in the control group (p<0.001 and p<0.001, respectively). C-reactive protein (CRP) was significantly higher in patients than in controls (p<0.001). Correlation analysis revealed a significant and inverse correlation between plasma ADMA concentrations and fasting blood glucose (p<0.001, r=-0.421), HbA1c (p=0.001, r=-0.361), CRP (p=0.003, r=-0.335), and CIMT measurements (p=0.024, r=-0.261). Among the patients with MS, 32 were diagnosed with type 2 DM; among whom 29 were receiving metformin treatment. ADMA levels in MS patients with and without metformin therapy were 4.5±1.7 nmol/mL and 7.3±1.2 nmol/mL, respectively; and the ADMA levels were significantly lower in the former than in the latter (p=0.007). Conclusion: MS is a cluster of diseases in which pro-atherosclerotic processes such as DM, hypertension, obesity, and hypercholesterolemia coexist. In our study, when increased CIMT values were considered as evidence for the presence of atherosclerosis in patients, the low serum ADMA levels may be related to metformin therapy, poor glycemic control, and/or problems in the immune-assay.
Authors and Affiliations
Serdar Arıcı, Ayşegül Kapuci, Sinem Kıyıcı, Gürcan Kısakol
Keywords
Related Articles
- EP ID EP688686
- DOI 10.4274/eamr.galenos.2019.39200
- Views 95
- Downloads 0
Inflammatory Markers in Hyperemesis Gravidarum
Objective: This study aims to investigate the role of inflammation in the pathophysiology of hyperemesis gravidarum (HEG). Methods: This prospective study was conducted in the Department of Obstetrics and Gynecology at...
Comparison of Bipolar TURP and Monopolar TURP Patients Who Underwent Surgery Due to Benign Prostatic Hyperplasia
Objective: Benign prostatic hyperplasia (BPH) is the one of the most common disease in the world. Transurethral resection of prostate (TURP) is the gold standard procedure in BPH surgery. So TURP methods are important. T...
Comparison of Cesarean Sections Performed in the Second Stage of Labor and Vacuum-assisted Vaginal Delivery
Objective: Cesarean section or operative vaginal delivery can be performed in the second stage of labor. The aim of our study was to compare cesarean deliveries performed in the second stage of labor and vacuum assisted...
The Association Between Contrast-induced Acute Kidney Injury and Neutrophil Gelatinase-associated Lipocalin
Objective: Neutrophil gelatinase-associated lipocalin (NGAL) has been reported as an useful marker to detect early contrast-induced acute kidney injury (CI-AKI). However most of the studies were performed in subjects tak...
Idiopathic Scrotal Calcinosis: A Review of the Literature with Seven Cases
Objective: Scrotal calcinosis is a rare benign disease characterized by calcified nodules on the scrotum skin. In this article, seven patients who were diagnosed as idiopathic scrotal calcinosis were reviewed with the re...