ATORVASTATIN ADSORPTION STUDIES ON CHITOSANS IN AN in vitro PHARMACEUTICAL MODEL

Abstract

During the pharmacological therapy of specific diseases, drugs are used which, with other preparations or foods, can create connections, in many cases changing or even blocking their action. On the other hand, the use of unsuitable polymers as excipients may result in drug-polymer incompatibilities. Interactions consisting mainly of the occurrence of the adsorption phenomenon and on the formation of complex bonds that reduce the effect of the drugs are of particular importance. The aim of the study was to investigate whether the active substance atorvastatin is incompatible with dietary supplements containing chitosan. The phenomenon of the adsorption of the drug was examined using a static model of a pharmaceutical gastrointestinal tract, in the concentration range generally ingested in a single dose. Measurement results of the amount of bound drug were used to determine the average percentage of adsorbed drug dose. The results of the study prove that the anticholinesterase drug is adsorbed on chitosan in the pH ranges used, and that the binding capacity depends on the chitosan variety, which indirectly affects the reaction of the environment. It was observed that the average size of sorption depending on the chitosan variety ranged from 38% to 86%. The fact that the lowest value of adsorption was at pH 6.4 can be explained by the chemical properties of chitosan, which shows a charge only at pH >6.7. Under such conditions, the phenomenon of electrostatic adsorption may occur in relation to the healing substances of weak acids. At a pH above 7.6, corresponding to the intestinal fluid-filled intestine, the mean sorption for the highest dose of chitosan was from 38–86%. The increase in the adsorbed amount of anticholinesterase drugs on the polymer along with the increase in pH from 7.6 to 8.0 can be explained by the chitosan swelling properties, which increase with an increase in the pH. As a result, the specific surface area of the polymer and its sorption capacity increase. Based on the above considerations, it can be concluded that there is an antagonistic interaction between the drug and the polymer studied, which involves the adsorption of a drug from this group on the polymer (chitosan) and a decrease in its bioavailability.

Authors and Affiliations

Jan Meler, Bożena Grimling, Maria Szcześniak, Paweł Biernat

Keywords

Related Articles

THE USE OF ACTIVE CARBON IMMOBILISED ON CHITOSAN BEADS FOR RB5 AND BV10 DYE REMOVAL FROM AQUEOUS SOLUTIONS

This paper presents the adsorption of dyes – the anionic Reactive Black 5 (RB5) and cationic Basic Violet 10 (BV10) dyes – on activated carbon (AC) immobilised on chitosan (CHs). The results were compared with the remova...

SYNTHESIS OF NANOCOMPOSITE CHITOSAN-TiO2 AND ITS APPLICATION AS PHOTODEGRADATION AGENT OF METHILEN BLUE IN AQUEOUS MEDIUM

Synthesis of nanocomposite chitosan-TiO2 have been done. Nanocomposite made of chitosan was isolated from crab shell namely α-chitosan and squid pens as β-chitosan. Nanocomposite was synthesized by combining the function...

STATE OF WATER IN CITRATE CROSSLINKED CHITOSAN MEMBRANE

The ionically crosslinked membranes were prepared of chitosan (Ch) and trisodium citrate (Ch/CIT). The characteristics of the state of water in crosslinked and uncrosslinked chitosan membranes with different water conten...

CHARACTERISATION OF CHITOSAN/HYALURONIC ACID BLEND FILMS MODIFIED BY COLLAGEN

In the present study, thin films based on the blends of chitosan (Ch) and hyaluronic acid (HA) with and without collagen (Coll) were characterised using tensile tests, attenuated total reflectance Fourier transform infra...

THE PROPERTIES OF THERMOSENSITIVE GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

The investigations showed that the addition of a 20%, 23% and 25% poloxamer 407 increases the adhesive properties of the investigated powders, but at the same time it increases their pH. The enrichment of the composition...

Download PDF file
  • EP ID EP537271
  • DOI 10.15259/PCACD.23.14
  • Views 70
  • Downloads 0

How To Cite

Jan Meler, Bożena Grimling, Maria Szcześniak, Paweł Biernat (2018). ATORVASTATIN ADSORPTION STUDIES ON CHITOSANS IN AN in vitro PHARMACEUTICAL MODEL. Progress on Chemistry and Application of Chitin and its Derivatives, 0(), 140-148. https://europub.co.uk/articles/-A-537271