THE INHIBITION OF HUMAN PLATELET AGGREGATION BY A LOW-MOLECULAR WEIGHT CHITOSAN

Abstract

Chitosan derivatives were obtained by chemical (MW of 6 kDa, DD 99% - Ch6/99; MW13 kDa, DD 98% - Ch13/98) and enzymatic (MW of 5 kDa, DD 85% - Ch5/85; MW of 10 kDa, DD 85% - Ch10/85) depolymeri-sation of chitosan with a MW of 334 and 1000 kDa. Chitosan derivatives (almost identical MW pairs and different DD) possessed insignificant an-ticoagulant activity, did not promote human platelet aggregation and re-duced ADP or collagen-induced platelet aggregation. The studied sam-ples at a concentration of 2 mg/ml reduced the aggregation of platelets more than twice induced in 2x10-6M and 1x10-5M concentrations; at weak activation in 2x10-6M, the Ch10/85 sample was the most effective. The Ch6/99 and Ch13/98 samples were 20 times more effective at the inhibi-tion of collagen-induced platelet aggregation than the Ch10/85 sample. The latter can be explained by the greater value of positive charge (DD) and polydispersity (Mw/Mn) of chitosan samples obtained by chemical de-polymerisation.

Authors and Affiliations

Natalia N. Drozd, Yulia S. Logvinova, Balzhima Shagdarova, Alla V. Il’ina, Valery P. Varlamov

Keywords

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  • EP ID EP534706
  • DOI 10.15259/PCACD.23.05
  • Views 97
  • Downloads 0

How To Cite

Natalia N. Drozd, Yulia S. Logvinova, Balzhima Shagdarova, Alla V. Il’ina, Valery P. Varlamov (2018). THE INHIBITION OF HUMAN PLATELET AGGREGATION BY A LOW-MOLECULAR WEIGHT CHITOSAN. Progress on Chemistry and Application of Chitin and its Derivatives, 0(), 55-65. https://europub.co.uk/articles/-A-534706