THE INHIBITION OF HUMAN PLATELET AGGREGATION BY A LOW-MOLECULAR WEIGHT CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2018, Vol 0, Issue
Abstract
Chitosan derivatives were obtained by chemical (MW of 6 kDa, DD 99% - Ch6/99; MW13 kDa, DD 98% - Ch13/98) and enzymatic (MW of 5 kDa, DD 85% - Ch5/85; MW of 10 kDa, DD 85% - Ch10/85) depolymeri-sation of chitosan with a MW of 334 and 1000 kDa. Chitosan derivatives (almost identical MW pairs and different DD) possessed insignificant an-ticoagulant activity, did not promote human platelet aggregation and re-duced ADP or collagen-induced platelet aggregation. The studied sam-ples at a concentration of 2 mg/ml reduced the aggregation of platelets more than twice induced in 2x10-6M and 1x10-5M concentrations; at weak activation in 2x10-6M, the Ch10/85 sample was the most effective. The Ch6/99 and Ch13/98 samples were 20 times more effective at the inhibi-tion of collagen-induced platelet aggregation than the Ch10/85 sample. The latter can be explained by the greater value of positive charge (DD) and polydispersity (Mw/Mn) of chitosan samples obtained by chemical de-polymerisation.
Authors and Affiliations
Natalia N. Drozd, Yulia S. Logvinova, Balzhima Shagdarova, Alla V. Il’ina, Valery P. Varlamov
HETEROGENEOUS DEACETYLATION OF CHITIN DEGRADED WITH HYDROGEN PEROXIDE IN A MICROWAVE FIELD
Two-step procedure of obtaining chitosan with tailored properties has been elaborated. In the first step chitin from the shells of krill (Euphausia superba) and common shrimp (Crangon crangon [L.]) was subjected simultan...
PHOSPHATE REMOVAL FROM AQUEOUS SOLUTIONS BY CHITIN AND CHITOSAN IN FLAKES
The article presents the effectiveness of phosphate adsorption on the flakes of chitin and chitosan. Studies performed determined adsorption capacity of chitin and chitosan, best among the tested adsorption pH and the eq...
THE PROPERTIES OF THERMOSENSITIVE GYNECOLOGICAL POWDERS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN
The investigations showed that the addition of a 20%, 23% and 25% poloxamer 407 increases the adhesive properties of the investigated powders, but at the same time it increases their pH. The enrichment of the composition...
ATORVASTATIN ADSORPTION STUDIES ON CHITOSANS IN AN in vitro PHARMACEUTICAL MODEL
During the pharmacological therapy of specific diseases, drugs are used which, with other preparations or foods, can create connections, in many cases changing or even blocking their action. On the other hand, the use of...
STUDY OF THE INFLUENCE OV UV RADIATION ON BIODEGRADABLE BLENDS BASED ON CHITOSAN AND STARCH
The biodegradable blends of chitosan and starch with different component ratios were prepared by casting method. Obtained thin films were UV-irradiated (λ = 254 nm) and changes in chemical structure were monitored using...