ATRIAL NATRIURETIC PEPTIDE IN METABOLIC SYNDROME OF IRAQI PATIENTS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 10
Abstract
Background: Metabolic syndrome is a cluster of conditions associated with increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels, increasing risk of heart disease, stroke and diabetes. The atrial natriuretic peptides are secreted from cardiomyocytes in response to cardiac wall stress and play an important role in the regulation of blood pressure, intravascular volume, and cardiac remodeling; the natriuretic peptides also may exert a direct influence on lipid and glucose metabolism. Objectives: The current study aimed to investigate the role of atrial natriuretic peptide levels in metabolic syndrome of Iraqi patients. Methods: This study was conducted at Al-Hussein Teaching Hospital, Kerbala – Iraq from June, 2016 to Dec., 2017. One hundred twenty four patients with metabolic syndrome were included in this study. The subjects were interviewed for full history and physical examination. Diabetes was defined by either a history of fasting glucose ≥ 126 mg/dl (7.0mmol/l) or the use of insulin or hypoglycaemic medications. Serum atrial natriuretic peptide (ANP) levels were measured by ELISA kit. In addition to body mass index, lipid profiles, blood pressure, fasting glucose was measured. Results: The results show that there is a significant decrease in serum levels of atrial natriuretic peptide hormone in diabetic metabolic syndrome patients compared with non-diabetic metabolic syndrome patients in both sexes (P value< 0.05). Conclusion: We conclude that there was a significant association between lower ANP concentration and metabolic components studied. These findings raise the possibility that low level of ANP are a manifestation of metabolic syndrome, which might have pathophysiological implications.
Authors and Affiliations
Fadhil Jawad Al-Tu’ma
Keywords
Related Articles
- EP ID EP665707
- DOI -
- Views 205
- Downloads 0
FREQUENCY OF MICROORGANISMS INVOLVED IN UTI AMONG DIABETIC PATIENTS AT A TERTIARY CARE CENTER
Aim of study: The prevalence of asymptomatic and symptomatic UTI is very high among diabetic patients. This study was conducted to assess the frequency of microorganism involved in urinary tract infection among diabetic...
PNEUMOMEDIASTINUM SECONDARY TO HYPEREMESIS GRAVIDARUM IN THE FIRST TRIMESTER: CASE REPORT
Here we present the case of a 28-year old patient developing pneumomediastinum secondary to hyperemesis gravidarum. Admitted for treatment several times for hyperemesis from the 9th week of pregnancy, when the patient wa...
DENTAL RADIOGRAPHY IN FORENSIC ODONTOLOGY
Teeth are the most indestructible part of the human body and are resistant to almost all environmental conditions like fire, desiccation, and decomposition. Hence teeth are the reliable source of forensic investigation....
ASSOCIATION BETWEEN SERUM LIPIDS AND FUNDUS CHANGES IN HYPERTENSIVE PATIENTS
Background: To evaluate fasting serum lipid profile and fundus changes in hypertensive patients, and grade the hypertensive status. Methods: One hundred consecutive subjects of hypertension, fitting inclusion criteria, w...
INHIBITORS FOR LEPB OF MYCOBACTERIUM TUBERCULOSIS H37RV
Tuberculosis caused by Mycobacterium tuberculosis is under an urgent need for developing new drug with new target and action, as most available drugs are ineffective due to development of drug resistance at different lev...