INHIBITORS FOR LEPB OF MYCOBACTERIUM TUBERCULOSIS H37RV
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2019, Vol 5, Issue 4
Abstract
Tuberculosis caused by Mycobacterium tuberculosis is under an urgent need for developing new drug with new target and action, as most available drugs are ineffective due to development of drug resistance at different levels. QSAR model was built and validated to find suitable ligands for inhibition of strategic target in M. tuberculosis. Fifteen molecules were obtained, these are non-mutagenic, non-carcinogenic, non-teratogenic and satisfied the ADME requirements. They docked strongly to the candidate target LepB (Rv2903c)/Spase I, a membrane bound protein. Binding affinities were (-6 to -7.8) kcal/mol, those molecules can be synthesized easily as the synthetic accessibility not exceed 5.5 out of 10.
Authors and Affiliations
Zahra M. Al-Khafaji
Keywords
Related Articles
- EP ID EP675461
- DOI -
- Views 160
- Downloads 0
PHYSICAL ACTIVITY PROFILE AMONG TAIF UNIVERSITY STUDENTS AT TAIF GOVERNORATE, SAUDI ARABIA
Background: Physical activity is daily occurred by applying various activities such as sport exercises, which need to use the particular physical skills, working at home, and doing other daily works.[3] However, physical...
AUDIT OF RENAL BIOPSY COMPLICATIONS AND OUTCOMES AT A TERTIARY UNIT
Background: The indications for performing a renal biopsy vary among nephrologists, determined in part by the presenting signs and symptoms. Renal biopsy gives vital information which helps in estimating the disease prog...
TELEDENTISTRY: A SYSTEMATIC REVIEW OF THE LITERATURE
Introduction: Teledentistry is a new technology providing a remote consultation and dental health care for patients. The aim of this study was to conduct a systematic review of the literature about teledentistry in order...
SPECTRUM OF COMPLICATIONS OF SEVERE DKA IN CHILDREN IN PEDIATRIC INTENSIVE CARE UNIT
Objectives: To describe the spectrum of complications of Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA. Methods: Retrospective review of the medical records of all children admitted with the d...
A DETAIL STUDY OF AYURVED CONCEPT OF VRUKKA AND ITS APPLIED ANATOMY
Ayurveda is the oldest surviving complete medical system in the world. Human body through dissection which forms the suitable essential basics and set a strong base for further medical knowledge. In Ayurveda Mutravaha Sa...