Attenuation of hypertensive response with esmolol and labetalol in low doses in orotracheal intubation: A comparative study
Journal Title: Indian Journal of Clinical Anaesthesia - Year 2018, Vol 5, Issue 2
Abstract
Introduction This was a prospective randomized double blind comparative clinical study to assess the efficacy of Esmolol and Labetalol in low doses for attenuation of sympathomimetic response to laryngoscopy and intubationMaterials and MethodsThis study was conducted on 50 ASA 1 patients of either sex undergoing elective surgeries under general anaesthesia Patients were randomized into two groups group E who received intravenous Esmolol 05 mgkg or group L who received intravenous Labetalol 025 mg kg prior to induction and hemodynamic parameters were recorded as per designed protocol to assess stress response to laryngoscopy and intubationResults Both the study groups had similar demographic profile Instat version 310 was used for statistical calculations The study data were analyzed using statistical methods of mean standard deviation Esmolol 05 mgkg abetalol 025 mgkg significantly attenuated the rise in heart rate systolic blood pressure and RPP during laryngoscopy and intubation However the difference was not statistically significant among the values for DBP and MAPConclusion From our clinical study it can be concluded that in lower doses intravenous Labetalol 025 mgkg is a better agent than intravenous Esmolol 05 mgkg in attenuating the sympathomimetic response to laryngoscopy and intubation Usual dose of esmolol used to obtund intubation response is 24mgkg while labetalol has been tried in all doses ranging from 025 05 075 and 1 mgkg17Keywords Esmolol Labetalol Stress response Laryngoscopy and Intubation
Authors and Affiliations
Suruchi Ambasta, Swagat Mahapatra
Keywords
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- EP ID EP476477
- DOI 10.18231/2394-4994.2018.0050
- Views 85
- Downloads 0
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