Attenuation of pressor response to laryngoscopy and intubation: A comparative study of efficacy of topical nitroglycerine, sublingual nifedipine and intravenous lignocaine
Journal Title: MedPulse -International Medical Journal - Year 2017, Vol 4, Issue 9
Abstract
Background: Laryngoscopy and tracheal intubation frequently induce a cardiovascular stress response and may cause profound alteration of the hemodynamic state as consequences of anesthetic drug effects. A lot of methods have been tried to attenuate the cardiovascular response to laryngoscopy and intubation. Material and Methods: Study was carried on 100 patients aged between 20 to 60 years and randomly divided into 4 groups of 25 each as Group I (Control group), Group II (nitroglycerine 2% topically), Group III (nifedipine sublingually), Group IV (2% xylocaine intravenously) prior to intubation. Pulse rate, systolic and diastolic blood pressure were recorded at different time intervals. Results: The highest increase in pulse rate was in control Group I and less increase in lignocaine Group IV. Comparison of control Group I with Nitroglycerine Group II, Nifedipine Group III, Lignocaine Group IV there was statistically highly significant difference in the changes in mean systolic blood pressure at all the time intervals. Discussion: Intravenous lignocaine was more effective in attenuating the pulse rate and rate pressure product response to laryngoscopy and intubation, while topical nitroglycerine was best in attenuating the blood pressure.
Authors and Affiliations
Ravindra B Jalkote, Varsha Keshavrao Warke
Keywords
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